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Effect of Avemar ® – a fermented wheat germ extract – on rheumatoid arthritis. Preliminary data
Objective.
To investigate the effect of the fermented wheat germ extract (Avemar ®) in patients with severe rheumatoid arthritis (RA).
Methods.
Fifteen female RA (Stein-brocker II-III) patients, who had unsuccesfully tried two different DMARD treatments, were enrolled in
an open-label, 1-year long, pilot clinical study. DMARD and steroid therapies were recorded and continued. All patients received Avemar ® as additional therapy. For measurement of efficacy the Ritchie Index, the Health Assessment Questionnaire (HAQ) and the assessment of morning stiffness were applied. Patients were evaluated at baseline, 6 and 12 months. For statistical
analyses the Wilcoxon test was used.
Results.
At both 6 and 12 months, Ritchie index, HAQ and morning stiffness showed significant improvements compared with the baseline values. Dosages of steroids could be reduced in about half of the patients. No side effects of Avemar ® were observed.
Conclusion. Supplementation of standard therapies with a continuous administration of Avemar ® is beneficial for RA patients.