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Heidelberg Diagnostic System *


HEIDELBERG pH DIAGNOSTIC SYSTEM
32nd ANNIVERSARY YEAR
GASTRIC ANALYSIS:

HYPOCHLORHYDRIA, HYPERCHLORHYDRIA, ACHLORHYDRIA AND H2 BLOCKERS

PLUS

INFORMATION REGARDING THE DIGESTIVE SYSTEM AND IT’S RELATIONSHIP TO THE HEIDELBERG pH DIAGNOSTIC SYSTEM

ABOUT THE HEIDELBERG pH CAPSULE

This system was developed at the famous University of Heidelberg in the city of Heidelberg, Germany. In the table of contents in the Training and Reference Manual, you will see a Screened Color Photo of the Famous Heidelberg Castle, positioned high on a hillside. The Bridge in the foreground crosses the beautiful Nekkar River and leads to the center of the City of Heidelberg. All of the development of the Famous Heidelberg pH Capsule originated at the University of Heidelberg Hospital. The first Publication included a 1,000 Patient Study emanating from the Department of Gastroenterology.

The Heidelberg pH Capsule is a micro-miniaturized radio transmitter, which is designed for swallowing. Well over a million capsules have been used to date. The pH capsule is activated, calibrated and then swallowed. The patient wears a Transceiver around his/her neck via a suspension strap. The pendant picks up the telemetric pH data from the patient’s abdomen. It converts the information to digital data, and then, this information is transmitted to a Computer Interface Module for signal processing. The Computer Interface Module transfers this Data to the Dedicated Computer. The Heidelberg pH Data can be Printed out any time during or after the test.

The pH capsule IS NOT “radioactive,” so there is no reason for concern. The information that is received on the graph is compared with your medical history. Your doctor will then be dealing with more complete and essential data in his/her diagnosis.

Heidelberg pH Capsules are used extensively throughout the world in Pharmaceutical Research, Pharmaceutical design, Preventive and Nutritional Medical Practices, and by many of the major Pharmaceutical Manufacturers, world-wide. There have been over 141 published clinical studies in the Archives with over 73 pertinent studies published since 1977.

CHRISTOPHER CALAPAI, D O
1900 Hempstead Turnpike
Suite 503
East Meadow, NY 11544
Phone: 516-794-0404
Fax: 516-794-0332

HYPOCHLORHYDRIA is the lack of adequate production of hydrochloric acid (HCL) by certain stomach cells.

HYPOCHLORHYDRIA (Obvious)

One of the causes of loss of acid production is the presence of Pernicious Anemia. When the Anemia is discovered and hopefully, medically controlled, usually, acid Production returns. Many people, in the process of aging, develop various stages of Hypochlorhydria; however, it is not confined to this aging group. Many young people also develop this problem. Bear in mind that the presence of HCL in the stomach generally inhibits (slows down or stops) the reflex of “rapid-dumping” of foods out of the stomach, rendering the critical first stage of digestion partially or totally incomplete. Also, HCL performs a natural sterilization of the foods that we swallow. This is quite important, because nothing that we eat is sterile. In the predigestion phase of the stomach, HCL, pepsin, certain enzymes, plus the intrinsic factor, which is essential for the absorption of Vitamin B-12, play key rolls in the conversion processes of proteins to amino acids and starches to sugars that can be utilized by our bodies (in conjunction with the duodenal, 2nd phase of digestion). Many allergies can be traced to patients with HYPOCHLORHYDRIA. The lack of these intricate predigestion processes, cause many of these undigested proteins to become allergens. These allergens often develop into bizarre effects (allergic reactions) upon millions of people throughout the world. Medically controlled desensitizing (‘allergy shots’) is often very helpful, especially against airborne allergens. Generally speaking, “HYPO” patients seem to be more prone to allergies and stomach contents’ “dumping” prematurely into the duodenum (which helps “set the stage” for undigested proteins). Gas, belching, bloating, common to “HYPER” and “G.I. Spasm” are very often equally present in “HYPO,” giving confusing signals.

HYPERCHLORHYDRIA (Challenged)

HYPERCHLORHYDRIA, or excess production of HCL, causes delayed or marked-delayed emptying time of the stomach contents for 6 to 24 hours, or much longer in many cases. The stomach-acid level will generally read pH 1.0 or lower—toward pure acid, pH 0.0, but not in all cases. Initial fasting tests will be challenged with an alkaline drink. The test can be accurately administered with a fasting-patient-level of pure acid, pH 0.0 up to pH 5.0. When challenged with an alkaline drink, we measure the time that it takes to return from the alkaline, or neutralized state, back to the acid side. This determines normal parietal cell performance. If this standard challenge must be administered 2,3,4 or more times, showing neutralizations and rapid returns to acid levels, the patient has HYPERCHLORHYDRIA.

HYPOCHLORHYDRIA (NOT Obvious)

On the other hand, you may encounter a single challenge that begins with a fasting level of pH 0.5 to pH 5.0. It will neutralize close to pH 7.0 or higher (toward 8.0) and will not come back down into the acid range for 6 to 8 hours, sometimes longer. These patients have a “Hidden” Hypochlorhydria.

The alkaline challenge (standard: 5 cc saturated solution of sodium bicarbonate) is essential to determine the “fasting and challenged” stomach acid levels and parietal cells’ capacities.

 

Regarding the “pushing” of their highly-acid meals through into the duodenum: The emptied or ‘pushed-through’ food will be heavy on the acid side, which will stimulate the duodenal production of pancreatin and liver bile. However, the duodenal buffering capacities cannot, volume wise, elevate the pH of the “pushed-through” foods (now highly saturated with HCL) to the normal physiologic pH level into the small intestine. The stomach-exit pH range (under this condition) will be approximately pH 1.5 to 2.8 (rather than an optimal pH 4.0 to pH 4.5). The small intestine normal-to-ideal pH range would be pH 5.8 to 7.0 at this point. One example of a delayed stomach emptying is a person who has a normal breakfast, becomes hungry at noon, orders lunch, and then has trouble eating because his stomach is full… the breakfast is still there! (And it really is, still there.) The acid condition of the food at the Duodenal Exit Region now becomes an irritant against a mucous membrane that ideally, should be ‘climbing’ close (in time) to the neutral (pH 7.0) range. This causes incomplete digestion, as described before, with accompanying gas, belching, bloating, flatulence and irritable bowels.

Normal Appearing Gastrogram (Challenged by Alkali Drink) Showing pH Measurements and Timing

When the Total Digestive System is in pH Balance, You can virtually expect higher levels of Conversion and Absorption of ingested foods and Medications. In addition, you can expect an appreciable enhancement of the Patients’ Immune Systems! This is a very encouraging step for all aspects of Successful Treatment!


ACHLORHYDRIA is the total absence of HCL production in the stomach.

One of the causes of loss of acid production in a Patient is the presence of Pernicious Anemia. Patients with Achlorhydria should have a routine Blood test. Treatment for the anemia will generally return stomach parietal cell function. Always check to see if blood work has been done recently. Research Studies using the Heidelberg pH System have shown A Predominant conditions of Patients with HIV Positive (AID’s) is Acute Hypochlorhydria, and Achlorhydria in the later stages.

REGARDING H2 BLOCKERS

Millions of people are taking H2 blockers (Cemetadine and Cemetadine-type drugs). These prescription drugs block the production of HCL, thus rendering patients with normal or excess acid conditions into HYPOCHLORHYDRIA and ACHLORHYDRIA (little or no acid, as stated on page one). Many times, for various clinical reasons, these H2 Blockers are necessary, useful and should not be criticized. While patients are under the control of these H2 Blockers, physicians can expect to see the same symptoms as they would see with HYPOCHLORHYDRIA or ACHLORHYDRIA patients (also consider the fact there is no sterilizing effect on the ingested food due to the lack of HCL). In screening patients for a Heidelberg pH Capsule Test, it is wise to have the patient(s) stop taking any H2 Blocker tablets or capsules for at least 3 to 4 days before the test, this will insure correct pH measurements. These H2 Blockers have a repository. If a test is done on the first to third day after discontinuance, it will likely show Achlorhydria or some degree q/”Hypochlorhydria, which will not reflect a true physiologic picture of your patient’s stomach condition. Now that Pepcid A.C. and Tagamet H.B. have been approved for ‘over-the-counter’ purchase, it would be very wise to inquire, from Heidelberg Test Candidates, Whether they have taken any of these H2 Blockers, as well as their prescription counterparts. This is very important.

STOMACH EMPTYING

When we eat food it is close to the neutral pH of 7.0. It can be slightly higher or lower, depending upon the type of food(s) that are involved If the foods that we eat were highly alkaline or acidic, they would have a bad, burning (caustic or acidic) effect on our mucous membranes. Therefore, we can consider that most of the foods that we eat are neutral. When food enters the stomach, a reflex action begins the churning of the food, and then, certain cells are stimulated into production of predigestion products, or juices. Consider, at this time only, the Hydrochloric Acid (HCL). The parietal cells produce HCL to mix with the foods. The foods now slowly become saturated with HCL. At a certain point, in normal patients, these specialized cells begin to wane in production and eventually cease production of HCL. In the ‘stomach-churning’ process, combined with the continuing effect of receiving neutral-pH food the still-incoming-volume of neutral food begins apH neutralizing or dilution effect. The pressure of the stomach contents, in concert with the now-rising pH, up to the levels of pH 4.0 to 4.5, work together to effect a relaxation of the pylorus (stomach emptying valve), allowing batches of food to slowly enter the duodenum. At this point, the pH is on the acid side, and ideally suited for natural (acidic) stimulation within the duodenum to produce pancreatic juices and liver bile to mix with the transiting stomach products. A 2:1 ratio of sodium Bicarbonate-Potassium Bicarbonate is one of the combined natural ingredients of the exocrine pancreatic juices, and it is used to elevate (in the mixing process) the duodenal-phase contents from pH 1.0 to pH 1.5 points toward neutral. The liver bile is slightly on the high side of neutral (pH 7.0), and secondarily, slightly helpful in this buffering phase. When the pancreatic exocrine buffering and saturation is completed the duodenal contents begin to transit into the small intestine. For approximately 10 inches beyond the duodenum, special cells reabsorb a small portion of the HCL, which in turn, aids in the gradual elevation of pH in the small intestine from pH 6.0 to pH 7.0 (ideally). This is said to be the optimum pH level for conversion of proteins to amino acids, starches to sugars, which can be utilized, etc. Conversions and absorptions can be made when the pH runs to low numbers, towards the acid side; however, the conversion efficiency seems to drop exponentially as this happens.

CONCLUSION

Therefore, pH plays an all-important role in how we handle and process foods to the nourishment of our bodies. In addition, medications, which depend upon pH for release and absorption, have optimal effects within the alimentary tract under normal pH conditions. Virtually everything that we eat is properly converted and absorbed in the small intestine. Due to abnormal pH profiles in many patients, sustained-release medications may tend to “dump,” or release medicaments all at once, or, on the other hand, release very little. A normal, or near normal, pH alimentary canal profile is very beneficial for food processing and medicament delivery. The Heidelberg pH Capsule is used routinely by many of the major Pharmaceutical Manufactures, in Europe, Japan, Canada and the United States, as a “design tool” in the development and formulation of pH-dependent drug releases.

The Heidelberg pH Capsule works like a roving reporter. It gives the doctor a direct Digital pH reading, along with a graphic recorder of its environment-time phase, utilizing a Frequency Modulated – Amplitude Modulated “Space Age” Telemetric Signal. While in the stomach, the pH capsule will report exact pH information and it will show immediate changes to alkaline or acid “challenges”. When the pH capsule is swallowed, it reaches the stomach in 2 to 3 seconds, the same time as a vitamin or antibiotic tablet or capsule.

This eliminates the need for a naso-gastric tube, which is inserted into the nose by a technician in a special procedures room in a Clinic or Hospital. A lot of swallowing is required to assist the Technician in getting the tube down into the stomach pouch. The procedure, after insertion (with lots of gagging and sometimes vomiting) requires aspirating (or Pumping out) the stomach contents for pH values. It is very questionable data for the most part, because the gagging most often generates the injection of duodenal juices into the stomach juice “mix”.

The Heidelberg pH capsule is truly a non-invasive telemetric pH-monitoring device, which eliminates the need of using a naso-gastric tube.

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