SERVICES*

Close-up TV News - Prolotheray lecture

Reversing Hypertension

Heavy Metals and all diseases

Close-Up TV News - Dr. Calapai's approach

News 12 Interview: Parkinson’s Disease, Glutathione and Chelation Therapy

News 12 Interview: Platelet-rich plasma therapy

Prolotherapy Interview News 12

News 12 Interview: Diabetes and Weight Loss
Vitamin C restores the contractile response to dobutamine and improves myocardial efficiency in patients with heart failure after anterior myocardial infarction *

Background
Excessive oxidative stress is considered one of the mechanisms of a decrease in contractile force without concomitant reduction in oxygen cost in failing myocardium. We hypothesized that the antioxidant vitamin C may help reverse hyporesponsiveness to β-adrenergic stimulation and improve myocardial efficiency in patients with heart failure (HF) after myocardial infarction (MI).

Methods and Results
Nineteen patients with mild to moderate HF due to previous MI (mean left ventricular [LV] ejection fraction 39%) were instrumented with conductance and coronary sinus thermodilution catheters. Left ventricular contractility, expressed as Ees,, the slope of end-systolic pressure-volume relationship, and mechanical efficiency, expressed as the ratio of LV stroke work (SW) to myocardial oxygen consumption (MV?o2), were measured in response to the intravenous infusion of dobutamine (4 μg/kg per min) before (Dob) and during (Dob + Vit C) the infusion of vitamin C (2.0-g bolus injection and subsequent 50-mg/min infusion through the jugular vein) (vitamin C group, n = 10). The infusion of vitamin C augmented the Ees response to dobutamine by 20% ± 8% (Dob 2.1 ± 0.3, Dob + Vit C 2.5 ± 0.4 mm Hg/mL, P < .01) and the SW/MV?o2 response by 21% ± 5% (Dob 36% ± 3%, Dob + Vit C 43% ± 4%, P < .01). In the control group (n = 9), Ees and SW/MV?o2 were measured in response to dobutamine before (Dob) and during (Dob + vehicle) the infusion of saline. No difference in Ees or SW/MV?o2 was observed between Dob and Dob + vehicle (Ees: Dob 2.1 ± 0.2, Dob + vehicle 2.1 ± 0.2 mm Hg/mL per square meter, P = nonsignificant) (SW/MV?o2: Dob 35% ± 4%, Dob + vehicle 33% ± 4%, P = nonsignificant).

Conclusion
The administration of the antioxidant vitamin C enhances the contractile response to dobutamine and improves myocardial efficiency in patients with HF.

 

* Legal Disclaimer: Chelation and Hyperbaric Therapy, Stem Cell Therapy, and other treatments and modalities mentioned or referred to in this web site are medical techniques that may or may not be considered “mainstream”. As with any medical treatment, results will vary among individuals, and there is no implication or guarantee that you will heal or achieve the same outcome as patients herein.

As with any procedure, there could be pain or other substantial risks involved. These concerns should be discussed with your health care provider prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

THE INFORMATION IN THIS WEBSITE IS OFFERED FOR GENERAL EDUCATIONAL PURPOSES ONLY AND DOES NOT IMPLY OR GIVE MEDICAL ADVICE. No Doctor/Patient relationship shall be deemed to have arisen simply by reading the information contained on these pages, and you should consult with your personal physician/care giver regarding your medical treatment before undergoing any sort of treatment or therapy.

Published on 09-07-2009
Authors: Toshiro Shinke MD, PhD, a, , Junya Shite MDa, Hideyuki Takaoka MDa, Katsuya Hata MDa, Nobutaka Inoue MDa, Ryohei Yoshikawa MDa, Hidenari Matsumoto MDa, Hiroyuki Masai MDa, Satoshi Watanabe MDa, Tohru Ozawa MDa, Hiromasa Otake MDa, Daisuke Matsumoto MDa, Ken-ichi Hirata MDa and Mitsuhiro Yokoyama MDa
Source: American Heart Journal Volume 154, Issue 4, October 2007, Pages 645.e1-645.e8