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Vitamin C infusion treatment enhances cortisol production of the adrenal via the pituitary ACTH route *

The present study is an extension of our past study on the clinical use of vitamin C infusion or injection treatment in autoimmune disease and allergy which suggests that the intravenous introduction of vitamin C may enhance the activity of the endogenous cortisol in such a way as to allow clinical control of immune disorders. This time, we investigated the relation between ACTH, cortisol and vitamin C in plasma in the course of vitamin C infusion or injection treatment with and without the use of methyl-prednisolone annex, a suppressor of the homeostatic mechanism of the pituitary ACTH.

A total of 4 experiments were conducted using a healthy male volunteer. Results obtained are as follows: 1) the practice of the steroid-free vitamin C infusion treatment induced a) distinct depletion of both cortisol and vitamin C from the circulation at the initial to moderate stages of the experiment, b) a small surge of plasma cortisol at the middle stage, and c) skyrocket-like rises of ACTH and cortisol of plasma at the terminal stage. 2) The use of methylprednisolone annex in the vitamin C infusion set completely suppressed the emergence of the plasma ACTH/cortisol surges of the terminal stage, but not the small surge of plasma cortisol. The synthetic steroid also suppressed the depletion of vitamin C and cortisol of the initial to moderate stages. 3) The terminal ACTH/cortisol surges of plasma were less distinct in the vitamin C infection experiment than in the vitamin C infusion experiment.(ABSTRACT TRUNCATED AT 250 WORDS)

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As with any procedure, there could be pain or other substantial risks involved. These concerns should be discussed with your health care provider prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

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Published on 12-24-2006