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Use of Autologous Platelet-Rich Plasma in the Treatment of Dormant Corneal Ulcers Connecticut *

Purpose To investigate the potential role of autologous platelet-rich plasma in promoting healing in dormant corneal ulcers.

Design
Prospective, consecutive, interventional, noncomparative, nonrandomized, observational study.

Participants
Forty eyes of 38 patients with dormant corneal ulcers.

Methods
Autologous platelet-rich plasma was used in a total of 40 eyes with dormant corneal ulcers divided into 2 groups: group I, 26 eyes treated with topical eyedrops of autologous platelet-rich plasma (12 neurotrophic, 9 herpetic, and 5 immunological ulcers), and group II, 14 eyes treated surgically with a solid clot of autologous platelet-rich plasma combined with amniotic membrane transplantation in perforated corneas or with impending perforation. The treatment was used in patients with chronic nonhealing ulcers (mean, 2 years of evolution) that had been unresponsive to conventional topical therapy. Autologous blood from each patient was obtained by venipuncture, and platelet-rich plasma was prepared from each blood sample without additives.

* Legal Disclaimer: Chelation and Hyperbaric Therapy, Stem Cell Therapy, and other treatments and modalities mentioned or referred to in this web site are medical techniques that may or may not be considered “mainstream”. As with any medical treatment, results will vary among individuals, and there is no implication or guarantee that you will heal or achieve the same outcome as patients herein.

As with any procedure, there could be pain or other substantial risks involved. These concerns should be discussed with your health care provider prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

THE INFORMATION IN THIS WEBSITE IS OFFERED FOR GENERAL EDUCATIONAL PURPOSES ONLY AND DOES NOT IMPLY OR GIVE MEDICAL ADVICE. No Doctor/Patient relationship shall be deemed to have arisen simply by reading the information contained on these pages, and you should consult with your personal physician/care giver regarding your medical treatment before undergoing any sort of treatment or therapy.

Published on 06-01-2009
Authors: Jorge L. Alio MD, PhD1, 2, Marta Abad PhD3, Alberto Artola MD, PhD1, 2, Jose L. Rodriguez-Prats MD1, Silvia Pastor PhD3 and Jose Ruiz-Colecha MD1
Source: Ophthalmology Volume 114, Issue 7, July 2007, Pages 1286-1293.e1