Close-up TV News - Prolotheray lecture

Reversing Hypertension

Heavy Metals and all diseases

Close-Up TV News - Dr. Calapai's approach

News 12 Interview: Parkinson’s Disease, Glutathione and Chelation Therapy

News 12 Interview: Platelet-rich plasma therapy

Prolotherapy Interview News 12

News 12 Interview: Diabetes and Weight Loss
Urinary Cadmium and Age-related Macular Degeneration *

To evaluate the association between urinary and blood cadmium (Cd) levels with age-related macular degeneration (AMD).

Prospective case-control study.

In 53 participants older than 60 years with AMD in both eyes and in 53 age-matched (± 3 years) controls without AMD, Cd levels were measured in blood and urine specimens (with and without creatinine adjustment) by using inductively coupled plasma-mass spectrometry. Data on age, gender, smoking status, and family history were obtained. By using color stereoscopic fundus photographs, the degree of AMD was graded using the Age-Related Eye Disease Study’s 4-stage AMD severity scale. The inclusion criterion for AMD cases was a photographic severity level of two to four in both eyes. Median blood and urine Cd and median urine Cd/creatinine concentrations in cases and controls were compared by using the rank-sum test, stratifying for smoking status.

Current and former smokers with AMD had median urine Cd/creatinine levels (1.18 μg/g; range, 0.84 to 1.44 μg/g) that were 97% higher than smokers without AMD (0.60 μg/g; range, 0.49 to 0.90 μg/g; P = .02), 111% higher than never smokers with AMD (0.56 μg/g; range, 0.40 to 0.80 μg/g; P < .001) and 107% higher than never smokers without AMD (0.57 μg/g; 0.40 to 0.65 μg/g; P < .001). Blood Cd levels, indicative of short-term exposure levels, were not associated with AMD (P ≥ .06).

A higher urinary Cd level, which reflects the total body burden of Cd, was associated with AMD in smokers. Accumulated Cd exposure may be important in the development of smoking-related AMD.

* Legal Disclaimer: Chelation and Hyperbaric Therapy, Stem Cell Therapy, and other treatments and modalities mentioned or referred to in this web site are medical techniques that may or may not be considered “mainstream”. As with any medical treatment, results will vary among individuals, and there is no implication or guarantee that you will heal or achieve the same outcome as patients herein.

As with any procedure, there could be pain or other substantial risks involved. These concerns should be discussed with your health care provider prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

THE INFORMATION IN THIS WEBSITE IS OFFERED FOR GENERAL EDUCATIONAL PURPOSES ONLY AND DOES NOT IMPLY OR GIVE MEDICAL ADVICE. No Doctor/Patient relationship shall be deemed to have arisen simply by reading the information contained on these pages, and you should consult with your personal physician/care giver regarding your medical treatment before undergoing any sort of treatment or therapy.

Published on 01-21-2011
Authors: Jay C. Erie, Jonathan A. Good, John A. Butz, David O. Hodge, Jose S. Pulido
Source: American Journal of ophthalmology, Volume 144, Issue 3, Pages 414-418.e1 (September 2007)