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Trace Elements, Heavy Metals and Other Biochemical Parameters in Malignant Glioma Patients *

Aim: We aimed to assess relevance of mineral, trace element and heavy metal levels in patients with malignant
gliomas. Methods: In this study, erythrocyte catalase (CAT), and carbonic anhydrase (CA), serum copper (Cu.),
zinc (Zn), lead (Pb), iron (Fe), cadmium (Cd), cobalt (Co), manganese (Mn), and magnesium (Mg) levels were
measured in 22 healthy humans and 22 malignant glioma patients. Metal concentrations were assessed by atomic
adsorption spectrophotometry, while biochemical methods were used for CAT and CA. Results: The Cd, Fe, Mg,
Mn, Pb and Zn levels were significantly elevated in the patients as a whole compared to controls(P<0.05), while
Cu was decreased and Co demonstrated no change. Although mean CAT activity were significantly lowered, CA
exhibited significant increase. Conclusions: The results of the current study indicate that antioxidant enzymes
may have a role in the genesis of considerable oxidative stress in patients with malignant glioma. CAT and CA
seem to play particular roles in the pathophysiology of this disease.

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As with any procedure, there could be pain or other substantial risks involved. These concerns should be discussed with your health care provider prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

THE INFORMATION IN THIS WEBSITE IS OFFERED FOR GENERAL EDUCATIONAL PURPOSES ONLY AND DOES NOT IMPLY OR GIVE MEDICAL ADVICE. No Doctor/Patient relationship shall be deemed to have arisen simply by reading the information contained on these pages, and you should consult with your personal physician/care giver regarding your medical treatment before undergoing any sort of treatment or therapy.

Published on 02-21-2013