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The use of magnesium sulfate in acute asthma: Rapid uptake of evidence in North American emergency departments *

Background Systematic reviews of approximately 13 randomized trials support treatment with intravenous magnesium sulfate (MgSO4) in patients with severe acute asthma; however, little is known about its actual clinical use.
Objective We sought to examine the use of intravenous MgSO4 in the emergency department (ED) and physician attitudes toward its use.
Methods Data for MgSO4 use were obtained from observational cohort studies of ED patients with acute asthma. Investigators were asked about MgSO4 through a brief Internet-based survey. The main outcomes were the percentage of sites reporting MgSO4 use and patient factors that potentially modified the use of this agent.
Results Among 9745 ED patients with acute asthma, 240 (2.5%) received MgSO4. Increasing age, previous intubation, higher initial respiratory rate, lower initial PEF, higher number of β-agonists in the ED, and use of systemic corticosteroids were associated with MgSO4 use (P < .01). Overall, 103 (87%) of 119 potential sites completed the survey. Most (92%) respondents stated their EDs had MgSO4 available, and 64% had recently used it. More respondents listed severity (96%) and failure to respond to initial β-agonists (87%) as factors prompting their use of MgSO4. Other factors, such as age, sex, and duration of exacerbation, less commonly influenced MgSO4 use.

* Legal Disclaimer: Chelation and Hyperbaric Therapy, Stem Cell Therapy, and other treatments and modalities mentioned or referred to in this web site are medical techniques that may or may not be considered “mainstream”. As with any medical treatment, results will vary among individuals, and there is no implication or guarantee that you will heal or achieve the same outcome as patients herein.

As with any procedure, there could be pain or other substantial risks involved. These concerns should be discussed with your health care provider prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

THE INFORMATION IN THIS WEBSITE IS OFFERED FOR GENERAL EDUCATIONAL PURPOSES ONLY AND DOES NOT IMPLY OR GIVE MEDICAL ADVICE. No Doctor/Patient relationship shall be deemed to have arisen simply by reading the information contained on these pages, and you should consult with your personal physician/care giver regarding your medical treatment before undergoing any sort of treatment or therapy.

Published on 08-18-2008
Authors: Brian H. Rowe MD, MSca, , , Carlos A. Camargo, Jr. MD, DrPHb and for the Multicenter Airway Research Collaboration (MARC), Investigators
Source: From the Department of Emergency Medicine, University of Alberta, and Capital Health, Edmonton bDepartment of Emergency Medicine, Massachusetts General Hospital, and the Channing Laboratory, Department of Medicine, Brigham and Womens Hospital, Harvard Medical School, Boston