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The role of vitamin D in pulmonary disease: COPD, asthma, infection, and cancer *

The role of vitamin D (VitD) in calcium and bone homeostasis is well described. In the last years, it has been
recognized that in addition to this classical function, VitD modulates a variety of processes and regulatory systems
including host defense, inflammation, immunity, and repair. VitD deficiency appears to be frequent in industrialized
countries. Especially patients with lung diseases have often low VitD serum levels. Epidemiological data indicate
that low levels of serum VitD is associated with impaired pulmonary function, increased incidence of inflammatory,
infectious or neoplastic diseases. Several lung diseases, all inflammatory in nature, may be related to activities of
VitD including asthma, COPD and cancer. The exact mechanisms underlying these data are unknown, however,
VitD appears to impact on the function of inflammatory and structural cells, including dendritic cells, lymphocytes,
monocytes, and epithelial cells. This review summarizes the knowledge on the classical and newly discovered
functions of VitD, the molecular and cellular mechanism of action and the available data on the relationship
between lung disease and VitD status.

* Legal Disclaimer: Chelation and Hyperbaric Therapy, Stem Cell Therapy, and other treatments and modalities mentioned or referred to in this web site are medical techniques that may or may not be considered “mainstream”. As with any medical treatment, results will vary among individuals, and there is no implication or guarantee that you will heal or achieve the same outcome as patients herein.

As with any procedure, there could be pain or other substantial risks involved. These concerns should be discussed with your health care provider prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

THE INFORMATION IN THIS WEBSITE IS OFFERED FOR GENERAL EDUCATIONAL PURPOSES ONLY AND DOES NOT IMPLY OR GIVE MEDICAL ADVICE. No Doctor/Patient relationship shall be deemed to have arisen simply by reading the information contained on these pages, and you should consult with your personal physician/care giver regarding your medical treatment before undergoing any sort of treatment or therapy.

Published on 01-17-2013