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Stem Cell Therapies for Post-Traumatic Arthritis *

Post-traumatic arthritis is a progressive and debilitating joint disease that commonly occurs following joint trauma, such as ligament injury, meniscal tear, or intra-articular fracture. However, there are few therapeutic approaches currently available that have been shown to alter the course of this disease. Recent studies have shown that several different types of adult stem cells possess regenerative capabilities for a wide range of disease states. In particular, several studies have shown that exogenously delivered stem cells can enhance regeneration and diminish the severity or progression of post-traumatic arthritis. The mechanisms by which these cells act are not fully understood, but appear to involve the secretion of bioactive factors or the alteration of the cytokine and growth factor production of endogenous cells. Here we review the animal studies that have investigated the potential of stem cell therapies for reducing the severity of PTA, as well as some of the potential mechanisms that may be involved in these responses, and the current clinical trials being performed in this area.

* Legal Disclaimer: Chelation and Hyperbaric Therapy, Stem Cell Therapy, and other treatments and modalities mentioned or referred to in this web site are medical techniques that may or may not be considered “mainstream”. As with any medical treatment, results will vary among individuals, and there is no implication or guarantee that you will heal or achieve the same outcome as patients herein.

As with any procedure, there could be pain or other substantial risks involved. These concerns should be discussed with your health care provider prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

THE INFORMATION IN THIS WEBSITE IS OFFERED FOR GENERAL EDUCATIONAL PURPOSES ONLY AND DOES NOT IMPLY OR GIVE MEDICAL ADVICE. No Doctor/Patient relationship shall be deemed to have arisen simply by reading the information contained on these pages, and you should consult with your personal physician/care giver regarding your medical treatment before undergoing any sort of treatment or therapy.

Published on 01-27-2016
Authors: Farshid Guilak Ph.D, Brian O. Diekman Ph.D. , Steven A. Olson M.D.
Source: Post-Traumatic Arthritis