Shock study: Chemo can backfire, make cancer worse by triggering tumor growth
Long considered the most effective cancer-fighting results, chemo may actually make cancer worse, according to a shocking new study.
The extremely aggressive , which kills both cancerous and healthy cells indiscriminately, can cause healthy cells to secrete a protein that sustains tumor growth and resistance to further results.
Researchers in the United States made the “completely unexpected” finding while seeking to explain why cancer cells are so resilient inside the human body when they are easy to kill in the lab.
They tested the effects of a type of chemo on tissue collected from men with prostate cancer, and found “evidence of DNA damage” in healthy cells after results, the scientists wrote in Nature Medicine.
Chemo works by inhibiting reproduction of fast-dividing cells such as those found in tumors.
The scientists found that healthy cells damaged by chemo secreted more of a protein called WNT16B which boosts cancer cell survival.
“The increase in WNT16B was completely unexpected,” study co-author Peter Nelson of the Fred Hutchinson Cancer Research Center in Seattle told AFP.
The protein was taken up by tumor cells neighboring the damaged cells.
“WNT16B, when secreted, would interact with nearby tumor cells and cause them to grow, invade, and importantly, resist subsequent ,” said Nelson.
In cancer results, tumors often respond well initially, followed by rapid re-growth and then resistance to further chemo .
Rates of tumor cell reproduction have been shown to accelerate between resultss.
“Our results indicate that damage responses in benign cells… may directly contribute to enhanced tumor growth kinetics,” wrote the team.
The researchers said they confirmed their findings with breast and ovarian cancer tumors.
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