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News 12 Interview: Diabetes and Weight Loss
Serum Zinc Level and Coronary Heart Disease Events in Patients With Type 2 Diabetes *

OBJECTIVE — Low serum zinc level may predispose nondiabetic subjects to cardiovascular diseases. Our aim was to investigate whether serum zinc level predicts coronary heart disease (CHD) events in subjects with type 2 diabetes

RESEARCH DESIGN AND METHODS — The original study population consisted of 1,059 patients with type 2 diabetes, aged 45–64 years. Mean duration of diabetes was 8 years. Serum zinc values were available from 1,050 subjects. CHD mortality and the incidence of nonfatal myocardial infarction (MI) were assessed in a 7-year follow-up.

RESULTS — During the follow-up, 156 patients died from CHD and 254 patients had a fatal or nonfatal MI. Patients with serum zinc concentration ≤14.1 μmol/l at baseline had a higher risk for death from CHD than patients with serum zinc level >14.1 μmol/l (20.8 and 12.8%, respectively; P = 0.001) The risks for fatal or nonfatal MI were 30.5 and 22.0%, respectively (P = 0.005). In Cox regression analyses, low serum zinc concentration was significantly associated with CHD mortality (relative risk [RR] 1.7, P = 0.002) and all CHD events (RR 1.37, P = 0.030), even after adjustment for confounding variables.

CONCLUSIONS — In this large cohort of type 2 diabetic patients, low serum zinc level was an independent risk factor for CHD events.

* Legal Disclaimer: Chelation and Hyperbaric Therapy, Stem Cell Therapy, and other treatments and modalities mentioned or referred to in this web site are medical techniques that may or may not be considered “mainstream”. As with any medical treatment, results will vary among individuals, and there is no implication or guarantee that you will heal or achieve the same outcome as patients herein.

As with any procedure, there could be pain or other substantial risks involved. These concerns should be discussed with your health care provider prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

THE INFORMATION IN THIS WEBSITE IS OFFERED FOR GENERAL EDUCATIONAL PURPOSES ONLY AND DOES NOT IMPLY OR GIVE MEDICAL ADVICE. No Doctor/Patient relationship shall be deemed to have arisen simply by reading the information contained on these pages, and you should consult with your personal physician/care giver regarding your medical treatment before undergoing any sort of treatment or therapy.

Published on 08-24-2009
Authors: Minna Soinio, MD1, Jukka Marniemi, PHD2, Markku Laakso, MD3, Kalevi Pyorala, MD3, Seppo Lehto, MD4 and Tapani Ronnemaa, MD1
Source: Diabetes Care March 2007 vol. 30 no. 3 523-528