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Role of Autologous Bone Marrow Stem Cell Transplantation in the Treatment of Active Ulcerative Colitis *

Background: Stem cell therapy was suggested to improve the quality of life to patients of UC through its powerful immunomodulatory effects and its ability to stimulate regeneration of intestinal mucosa.

Aim of the work: To evaluate autologous bone marrow stem cells transplantation as a treatment option for cases of active ulcerative colitis in comparison with the conventional treatment, and to evaluate its safety and feasibility.

Patients and methods: 10 patients of active ulcerative colitis were intravenously injected with autologous bone marrow mononuclear layer containing stem cell and continued on their conventional treatment. Clinical, laboratory and endoscopic assessment of disease severity were done before and after 3 months after SCT.

Results: There was statistically signicant improvement in the number of diarrheal motions, heart rate, ESR, CRP, disease extent and severity after SCT with p value0.026, 0.009, 0.006, 0.012, 0.038 respectively with no recorded side effects or complications.

Conclusion: Bone marrow stem Cell transplantation for patients of ulcerative colitis is a safe and feasible procedure. It can improve the quality of life of the patients as well as the disease activity assessed by clinical assessment, laboratory tests, endoscopic extent and severity.

* Legal Disclaimer: Chelation and Hyperbaric Therapy, Stem Cell Therapy, and other treatments and modalities mentioned or referred to in this web site are medical techniques that may or may not be considered “mainstream”. As with any medical treatment, results will vary among individuals, and there is no implication or guarantee that you will heal or achieve the same outcome as patients herein.

As with any procedure, there could be pain or other substantial risks involved. These concerns should be discussed with your health care provider prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

THE INFORMATION IN THIS WEBSITE IS OFFERED FOR GENERAL EDUCATIONAL PURPOSES ONLY AND DOES NOT IMPLY OR GIVE MEDICAL ADVICE. No Doctor/Patient relationship shall be deemed to have arisen simply by reading the information contained on these pages, and you should consult with your personal physician/care giver regarding your medical treatment before undergoing any sort of treatment or therapy.

Published on 04-26-2017
Authors: Alaa E Ismail, Mohsen M Maher, Wesam A Ibrahim, Shereen ASaleh, Khaled Makboul, Doaa Zakaria Zaki, Marina Nashed, Nehal Ibrahim and Mohammed Fathy