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Rapid, transient induction of ER stress in the liver and kidney after acute exposure to heavy metal: Evidence from transgenic sensor mice *

Endoplasmic reticulum (ER) stress-responsive alkaline phosphatase (ES-TRAP) serves as a sensitive indicator for ER stress. In response to heavy metals including cadmium, nickel and cobalt, hepatocytes and renal tubular cells expressing ES-TRAP exhibited ER stress and decreased ES-TRAP activity. In ES-TRAP transgenic mice, acute exposure to cadmium showed rapid, transient decreases in the activity of serum ES-TRAP. It was inversely correlated with the induction of endogenous ER stress markers in the liver and kidney. Our result provides first evidence for the acute, reversible induction of ER stress in vivo after exposure to heavy metal.

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Published on 09-22-2008
Authors: Nobuhiko Hiramatsua, Ayumi Kasaia, Shuqi Dub, c, Masayuki Takedab, Kunihiro Hayakawaa, Maro Okamuraa, Jian Yaoa and Masanori Kitamura
Source: Federation of European Biochemical Societies Published by Elsevier B.V.