Close-up TV News - Prolotheray lecture

Reversing Hypertension

Heavy Metals and all diseases

Close-Up TV News - Dr. Calapai's approach

News 12 Interview: Parkinson’s Disease, Glutathione and Chelation Therapy

News 12 Interview: Platelet-rich plasma therapy

Prolotherapy Interview News 12

News 12 Interview: Diabetes and Weight Loss
Randomized prospective double-blind placebo-controlled study of dextrose prolotherapy for knee osteoarthritis with or without acl laxity. *

Context – Use of prolotherapy (injection of growth factors or growth factor stimulators).

O b j e c t i ve – Determine the effects of dextrose pro l o t h e rapy on knee osteoarthritis with or without anterior cruciate ligament (ACL) laxity.

Design – Pro s p e c t i ve randomized double-blind placebo-controlled trial.

Setting – Outpatient physical medicine clinic.

Patients or other participants – Six months or more of pain along with either grade 2 or more joint narrowing or grade 2 or more osteophytic change in any knee compartment. A total of 38 knees were completely void of cartilage ra d i o g raphically in at least 1 compartment.

Intervention – Three bimonthly injections of 9 cc of either 10% dext rose and .075% lidocaine in bacteriostatic water (active solution) versus an identical control solution absent 10% dextrose. The dextrose – treated joints then received 3 further bimonthly injections of 10% dextrose in open-label fashion.

Main Outcome Measures – Visual analogue scale for pain and swelling, frequency of leg buckling, goniometrically measured flexion, ra d i o g raphic measures of joint narrowing and osteophytosis, and KT1000-measured anterior displacement difference (ADD).

Results – All knees: Hotelling multivariate analysis of paired observations between 0 and 6 months for pain, swelling, buckling episodes, and knee flexion range re vealed significantly more benefit from the dext rose injection (P=.015). By 12 months (6 injections) the dextrose – t reated knees impro ved in pain (44% decrease), swelling complaints ( 63% decrease), knee buckling frequency (85% decrease), and in flexion range (14 degree increase). Analysis of blinded radiographic readings of 0- and 12-month films revealed stability of all radiographic variables except for 2 variables which impro ved with statistical significance. (Lateral patellofemoral cartilage thickness [P=.019] and distal femur width in mm [P=.0 21]. Knees with ACL laxity: 6-month (3 injection) data re vealed no significant impro vement. Ho w e ve r, Hotelling multivariate analysis of paired values at 0 and 12 months for pain, swelling, joint flexion, and joint laxity in the dextro s e – t re a t e d knees, re vealed a statistically significant impro vement (P=.0 21 ) . Individual paired t tests indicated that blinded measurement of goniometric knee flexion range impro ved by 12.8 degrees (P=.005), and ADD impro ved by 57% (P=.025). Eight out of 13 dextro s e – t re a t e d knees with ACL laxity were no longer lax at the conclusion of 1 year. Conclusion ¥ Prolotherapy injection with 10% dextrose resulted in clinically and statistically significant impro vements in knee osteoarthritis. Pre l i m i n a ry blinded ra d i o g raphic readings (1- y e a r films, with 3-year total follow-up period planned) demonstra t e d improvement in several measures of osteoarthritic severity. ACL laxity, when present in these osteoarthritic patients, impro ved. (Al t e r n Ther Health Med.

* Legal Disclaimer: Chelation and Hyperbaric Therapy, Stem Cell Therapy, and other treatments and modalities mentioned or referred to in this web site are medical techniques that may or may not be considered “mainstream”. As with any medical treatment, results will vary among individuals, and there is no implication or guarantee that you will heal or achieve the same outcome as patients herein.

As with any procedure, there could be pain or other substantial risks involved. These concerns should be discussed with your health care provider prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

THE INFORMATION IN THIS WEBSITE IS OFFERED FOR GENERAL EDUCATIONAL PURPOSES ONLY AND DOES NOT IMPLY OR GIVE MEDICAL ADVICE. No Doctor/Patient relationship shall be deemed to have arisen simply by reading the information contained on these pages, and you should consult with your personal physician/care giver regarding your medical treatment before undergoing any sort of treatment or therapy.

Published on 04-07-2006