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POLY MVA – a dietary supplement containing α-lipoic acid palladium complex, enhances cellular DNA *

POLY MVA, a commercially available health supplement containing α-lipoic acid palladium complex, was evaluated for its potential to enhance the repair of radiation-induced DNA damage. Treatment of human peripheral blood leukocytes with POLY MVA immediately after radiation exposure enhanced the repair of cellular DNA as revealed by comet assay. Post-irradiation administration of POLY MVA to mice resulted in faster cellular DNA repair, as revealed from the increased Cellular Repair Index (CRI) of blood leukocytes and bone marrow cells. Exposure of mice to 2 Gy whole-body gamma radiation resulted in the formation of strand breaks of cellular DNA of bone marrow cells, and the unrepaired strand breaks eventually lead to the formation of micronuclei in the reticulocytes. Administration of POLY MVA under post-irradiation conditions showed a decrease in the number of micronucleated reticulocytes. Thus, the studies under ex vivo and in vivo conditions revealed that the enhancement of DNA repair could be one of the mechanisms underlying radioprotection by POLY MVA.

* Legal Disclaimer: Chelation and Hyperbaric Therapy, Stem Cell Therapy, and other treatments and modalities mentioned or referred to in this web site are medical techniques that may or may not be considered “mainstream”. As with any medical treatment, results will vary among individuals, and there is no implication or guarantee that you will heal or achieve the same outcome as patients herein.

As with any procedure, there could be pain or other substantial risks involved. These concerns should be discussed with your health care provider prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

THE INFORMATION IN THIS WEBSITE IS OFFERED FOR GENERAL EDUCATIONAL PURPOSES ONLY AND DOES NOT IMPLY OR GIVE MEDICAL ADVICE. No Doctor/Patient relationship shall be deemed to have arisen simply by reading the information contained on these pages, and you should consult with your personal physician/care giver regarding your medical treatment before undergoing any sort of treatment or therapy.

Published on 05-09-2013