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Platelet-Rich Plasma in Orthopedics Long Island *

Autologous platelet-rich plasma (PRP) has become a popular clinical treatment in a variety of soft tissue and hard tissue applications. Clinicians use PRP to harvest the platelets' natural ability to promote hemostasis and to release cytokines into the wound bed with hopes of stimulating the rate of healing and improving tissue quality. Platelet-derived growth factor, transforming growth factor β1, vascular endothelial growth factor, basic fibroblast growth factor, epidermal growth factor, insulin-like growth factor and connective tissue growth factor are among the more notable cytokines released from platelets. To understand the utility of PRP in orthopedics, a review of the preclinical studies with PRP reveals a wide breadth of models where PRP enhances the outcomes.

However, it is apparent that PRP is most successful when paired with the appropriate matrices and/or cell therapies for optimal results. Reviews of peer-reviewed clinical studies, ranging from Level I evidence clinical trials to Level IV case series reports, also reveal a wide range of clinical utility for PRP. Future clinical trials should attempt to refine the clinical application of PRP for each indication for use. These studies must be designed with the appropriate outcome measures and follow-up time-points to capture the benefits of PRP. Given the data published to date, PRP appears to be a powerful autologous therapy for surgeons looking to enhance bone and soft tissue formation. Future investigations will further define PRP's optimal role in medicine.

* Legal Disclaimer: Chelation and Hyperbaric Therapy, Stem Cell Therapy, and other treatments and modalities mentioned or referred to in this web site are medical techniques that may or may not be considered “mainstream”. As with any medical treatment, results will vary among individuals, and there is no implication or guarantee that you will heal or achieve the same outcome as patients herein.

As with any procedure, there could be pain or other substantial risks involved. These concerns should be discussed with your health care provider prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

THE INFORMATION IN THIS WEBSITE IS OFFERED FOR GENERAL EDUCATIONAL PURPOSES ONLY AND DOES NOT IMPLY OR GIVE MEDICAL ADVICE. No Doctor/Patient relationship shall be deemed to have arisen simply by reading the information contained on these pages, and you should consult with your personal physician/care giver regarding your medical treatment before undergoing any sort of treatment or therapy.

Published on 05-27-2009
Authors: Jennifer E. Woodell-May4 and William S. Pietrzak5
Source: Musculoskeletal Tissue Regeneration Biological Materials and Methods