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Occupational Exposure to Lead Compounds and Risk of Cancer among Men: A Population-based Case-Control Study *

The International Agency for Research on Cancer recently classified inorganic lead as a probable carcinogen,
while organic lead remained unclassifiable. Uncertainty persists because of limited epidemiologic evidence. The
authors addressed the relation between occupational exposure to lead and the risk of 11 types of cancer among
men in a case-control study conducted in Montreal, Quebec, Canada, in the 1980s. Incident cases (n ¼ 3,730) and
general population controls (n ¼ 533) were interviewed to elicit information on job history and potential confounders.
Expert chemists translated each job into a list of substances to which the subject had potentially been exposed.
Exposure to lead was classified into three categories: organic lead (3% of subjects ever exposed), inorganic lead
(17%), and lead in gasoline emissions (39%). Odds ratios and 95% confidence intervals were estimated by logistic
regression using two control groups: general population controls and cancer controls. Stomach cancer was
associated with organic lead when the authors used population controls (odds ratio (OR) ¼ 3.0, 95% confidence
interval (CI): 1.2, 7.3) and cancer controls (OR ¼ 2.0, 95% CI: 1.1, 3.8) and with substantial exposure to lead in
gasoline emissions when they used cancer controls (OR ¼ 2.9, 95% CI: 1.4, 5.9). There was no association with
inorganic lead and little evidence for associations with other cancer types.

* Legal Disclaimer: Chelation and Hyperbaric Therapy, Stem Cell Therapy, and other treatments and modalities mentioned or referred to in this web site are medical techniques that may or may not be considered “mainstream”. As with any medical treatment, results will vary among individuals, and there is no implication or guarantee that you will heal or achieve the same outcome as patients herein.

As with any procedure, there could be pain or other substantial risks involved. These concerns should be discussed with your health care provider prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

THE INFORMATION IN THIS WEBSITE IS OFFERED FOR GENERAL EDUCATIONAL PURPOSES ONLY AND DOES NOT IMPLY OR GIVE MEDICAL ADVICE. No Doctor/Patient relationship shall be deemed to have arisen simply by reading the information contained on these pages, and you should consult with your personal physician/care giver regarding your medical treatment before undergoing any sort of treatment or therapy.

Published on 02-05-2010
Authors: M.-C. Rousseau, M.-E. Parent, L. Nadon, B. Latreille and J. Siemiatycki
Source: Received for publication November 8, 2006