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Non-ablative collagen remodeling initiated by two different laser effects: comparative study on mouse model *

Many lasers have claimed the clinical efficacy on skin rejuvenation. Generally, there are two main laser effects consistent with clinical applications. Systematic and comparative studies are needed to compare different laser effects and probe into the mechanism of laser skin rejuvenation. To conduct a comparative study of collagen remodeling with two different laser effects on mice model in vivo. After depilation, the back skin of KM mice was used for the study. The 1064 nm Q-switched (5 ns) and long-pulsed (0.3 ms) Nd:YAG lasers were applied based on optimal tissue reaction fluence test to irradiate one side of the mice back and leave the other side as the control. Then the collagen remodelling were evaluated at 0, 1, 7, 21, 30 and 60 days, with biophysical parameters' measurements, histological and biochemical examination.

The two lasers applied showed statistical improvements in skin elasticity, dermal thickness and synthesis of hydroxyproline compared with their own controls. Between the two lasers, the Q-switched 1064-nm laser resulted in greater improvements than that of the long-pulsed 1064-nm laser after two months of treatments. Collagen type III increased markedly after the Q-switched 1064-nm laser treatment whereas more collagen type I was elicited by the long-pulsed 1064-nm laser. Q-switched 1064-nm laser was more effective in collagen remodeling compared with long-pulsed 1064-nm laser. Photo-mechanic reaction can cause more synthesis of collagen type III whereas the photo-thermal effect is in favor of formation of collagen type I.

* Legal Disclaimer: Chelation and Hyperbaric Therapy, Stem Cell Therapy, and other treatments and modalities mentioned or referred to in this web site are medical techniques that may or may not be considered “mainstream”. As with any medical treatment, results will vary among individuals, and there is no implication or guarantee that you will heal or achieve the same outcome as patients herein.

As with any procedure, there could be pain or other substantial risks involved. These concerns should be discussed with your health care provider prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

THE INFORMATION IN THIS WEBSITE IS OFFERED FOR GENERAL EDUCATIONAL PURPOSES ONLY AND DOES NOT IMPLY OR GIVE MEDICAL ADVICE. No Doctor/Patient relationship shall be deemed to have arisen simply by reading the information contained on these pages, and you should consult with your personal physician/care giver regarding your medical treatment before undergoing any sort of treatment or therapy.

Published on 09-15-2008
Authors: Huaxu Liu Yongyan Dang Liya Jiang Zhan Wang Qiushi Ren Shanghai Jiao Tong Univ., Shanghai;
Source: Biophotonics, Nanophotonics and Metamaterials, 2006. Metamaterials 2006. International Symposium on