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Methyl mercury influences growth-related signaling in MCF-7 breast cancer cells *

Environmental contaminants have been shown to alter growth-regulating signaling pathways through molecular mechanisms that are mainly unclear. Here we report that within a narrow concentration range (0.5-1 M) methyl mercury (MeHg) significantly stimulated growth of MCF-7 cells, induced Ca2+ mobilization, and activated extracellular signal-regulated kinase ? (Erk1/2). MeHg modulated E2-dependent stimulation of growth in a dose-dependent manner, although MeHg neither suppresses nor increases constitutive E2 metabolism. MeHg demonstrated weak estrogen receptor (ER)-binding ability.

However, long preincubation with antiestrogens LY156,758 and ICI164,384 decreased MeHg-induced foci formation, Ca2+ mobilization, and Erk1/2 activation, confirming involvement of ERs. The MeHg-induced increase in [Ca2+]i was observed to coincide with enhanced Erk1/2 phosphorylation. These data suggest that MeHg can significantly modulate the intracellular signaling environment in MCF-7 cells, resulting in a dose-dependent alteration of ER-mediated estrogenic capacity and therefore should be considered as a potential estrogen-disrupting compound. © 2005 Wiley Periodicals, Inc. Environ Toxicol 20: 32-44, 2005.

* Legal Disclaimer: Chelation and Hyperbaric Therapy, Stem Cell Therapy, and other treatments and modalities mentioned or referred to in this web site are medical techniques that may or may not be considered “mainstream”. As with any medical treatment, results will vary among individuals, and there is no implication or guarantee that you will heal or achieve the same outcome as patients herein.

As with any procedure, there could be pain or other substantial risks involved. These concerns should be discussed with your health care provider prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

THE INFORMATION IN THIS WEBSITE IS OFFERED FOR GENERAL EDUCATIONAL PURPOSES ONLY AND DOES NOT IMPLY OR GIVE MEDICAL ADVICE. No Doctor/Patient relationship shall be deemed to have arisen simply by reading the information contained on these pages, and you should consult with your personal physician/care giver regarding your medical treatment before undergoing any sort of treatment or therapy.

Published on 02-21-2008