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Metallothionein and Anti-Metallothionein, Complementary Elements of Cadmium-Induced Renal Disease *

Metallothionein (MT) is a low–molecular weight, cysteine-rich stress response protein with a high affinity for divalent heavy metals. MT was originally identified as a cadmium-rich protein in the equine renal cortex. A large amount of subsequent work has shown MT to serve in many cell types in the management of essential divalent metal cations, to interfere with the toxic effects of xenobiotics, heavy metals, and free radicals, and to serve as a regulator of specific transcription factors. As a consequence of these various activities, MT synthesis has an impact on developmental processes and on the cellular responses to stressful conditions (reviewed in (Klaassen et al., 1999Go; Vasak, 2005Go)).

MT is primarily synthesized on free polysomes (Shapiro et al., 1980). Based on these observations, MT has often been considered to function exclusively as an intracellular protein. While MT lacks the signal peptide sequences or other protein trafficking .

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As with any procedure, there could be pain or other substantial risks involved. These concerns should be discussed with your health care provider prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

THE INFORMATION IN THIS WEBSITE IS OFFERED FOR GENERAL EDUCATIONAL PURPOSES ONLY AND DOES NOT IMPLY OR GIVE MEDICAL ADVICE. No Doctor/Patient relationship shall be deemed to have arisen simply by reading the information contained on these pages, and you should consult with your personal physician/care giver regarding your medical treatment before undergoing any sort of treatment or therapy.

Published on 09-15-2008
Authors: Michael A. Lynes1 and Xiuyun Yin
Source: Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut 06269-3125