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Mesenchymal stem cells exert a remarkable regenerative effect requiring minimal CNS integration: Commentary on: “Mesenchymal stem cells protect CNS neurons against glutamate excitotoxicity by inhibiting glutamate receptor expression and function” by Voulgari-Kokota et al. *

The concept of repair of the nervous system by adult stem cells has recently evolved from the original hypothesis that tissue regeneration could have been achieved through stem cell differentiation into neural cells to the current vision that they act mainly by means of paracrine mechanisms. In a recent paper from Voulgari-Kokota and colleagues in the July issue of Experimental Neurology it was shown that bone marrow-derived mesenchymal stem cells (MSC) can protect against glutamate excitotoxicity in a mouse model of temporal lobe epilepsy and that conditioned medium from MSC could rescue primary cortical neurons from glutamate-receptor induced cell death. Other studies have emphasized that MSC secretome may suffice to recapitulate many of the effects carried out by these cells on immune and tissue resident cells. However, MSC priming by local cues, upon interaction with the host environment, represents a prerequisite to maximally enhance their therapeutic plasticity. Future studies will have to resolve if stem cell transplantation is still preferable over the administration of their secreted factors.


* Legal Disclaimer: Chelation and Hyperbaric Therapy, Stem Cell Therapy, and other treatments and modalities mentioned or referred to in this web site are medical techniques that may or may not be considered “mainstream”. As with any medical treatment, results will vary among individuals, and there is no implication or guarantee that you will heal or achieve the same outcome as patients herein.

As with any procedure, there could be pain or other substantial risks involved. These concerns should be discussed with your health care provider prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

THE INFORMATION IN THIS WEBSITE IS OFFERED FOR GENERAL EDUCATIONAL PURPOSES ONLY AND DOES NOT IMPLY OR GIVE MEDICAL ADVICE. No Doctor/Patient relationship shall be deemed to have arisen simply by reading the information contained on these pages, and you should consult with your personal physician/care giver regarding your medical treatment before undergoing any sort of treatment or therapy.

Published on 12-10-2014