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News 12 Interview: Diabetes and Weight Loss
Mesenchymal Stem Cells Benefit Diabetes and Alzheimer’s Disease *

Type 2 diabetes mellitus (T2DM) is characterized by chronic
hyperglycemia, which induces neuron, kidney and eye dysfunction.
Hyperglycemia is also a risk factor for dementia. T2DM
also causes brain insulin resistance, oxidative stress and cognitive
impairment. Futhermore, oxidative stress causes a complex dysregulation
of cell metabolism resulting in insulin resistance and
beta cell dysfunction. Alzheimer’s Disease (AD) is the most
common form of dementia among older people worldwide, and
oxidative stress is an important pathogenic factor in AD. Oxygen
metabolism generates free radicals such as hydroxylradical, superoxide
radical, and reactive nitrogen species, inducing ROS. An
imbalance between oxidant and antioxidant agents could generate
oxidative stress, which damages macromolecules and disrupts the
reduction/oxidation (redox) signaling. Mitochondria contain
many redox enzymes, and generate ROS when there are inefficiencies
in oxidative phosphorylation. Mitochondrial dysfunction
occurs early and has a primary role in the pathogenesis of AD. T2DM patients show increased incidence of AD, and one
report has shown the role of insulin in that it links T2DM with
AD through mitochondrial alterations, oxidative stress and glucose
metabolism. The insulin effect not only impacts glucose
metabolism, but also has neuroprotective and neuromodulatory

* Legal Disclaimer: Chelation and Hyperbaric Therapy, Stem Cell Therapy, and other treatments and modalities mentioned or referred to in this web site are medical techniques that may or may not be considered “mainstream”. As with any medical treatment, results will vary among individuals, and there is no implication or guarantee that you will heal or achieve the same outcome as patients herein.

As with any procedure, there could be pain or other substantial risks involved. These concerns should be discussed with your health care provider prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

THE INFORMATION IN THIS WEBSITE IS OFFERED FOR GENERAL EDUCATIONAL PURPOSES ONLY AND DOES NOT IMPLY OR GIVE MEDICAL ADVICE. No Doctor/Patient relationship shall be deemed to have arisen simply by reading the information contained on these pages, and you should consult with your personal physician/care giver regarding your medical treatment before undergoing any sort of treatment or therapy.

Published on 02-02-2017
Authors: Ming Li, MD, Ph.D