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Mesenchymal and Adipose Stem Cell Strategies for Peripheral Nerve Regeneration *

Peripheral nerve injury (PNI) is a common sequela of soft tissue and bony trauma. The morbidity and loss of function secondary to PNI significantly limit patient quality of life. Strategies that restore or augment nerve regeneration and enable motor/sensory recovery after injury can help patients to return to functional/employable status while improving performance, morale, mobility, agility and capability. Suboptimal nerve regeneration after reconstructive transplantation remains one of the key obstacles to functional outcomes. Distal denervated muscles have impaired/no function and will undergo denervation atrophy if the nerves do not reach the motor end plates in time. Several drugs/biologics/growth factors (tacrolimus, chondroitinase, insulin-like growth factor-1, IGF1) as well as cellular therapies (Schwann cells (SC), mesenchymal stromal cells (MSC) of adipose, or bone marrow origin) have shown promise and potential in enhancing nerve regeneration via different mechanisms and distinct biochemical pathways. Combinations of these treatments may also provide an additive or even synergistic effect on the neuroregenerative process. Undifferentiated MSCs have inherent advantages over SCs or other cell types. These include higher yield, superior expansion characteristics and innate self-renewal, angiogeneic and immunomodulatory properties. Here in, we focus on the current experimental evidence for MSCs as promising potential therapies in accelerating or maximizing peripheral nerve regeneration and subsequent functional outcomes in reconstructive transplant indications.

* Legal Disclaimer: Chelation and Hyperbaric Therapy, Stem Cell Therapy, and other treatments and modalities mentioned or referred to in this web site are medical techniques that may or may not be considered “mainstream”. As with any medical treatment, results will vary among individuals, and there is no implication or guarantee that you will heal or achieve the same outcome as patients herein.

As with any procedure, there could be pain or other substantial risks involved. These concerns should be discussed with your health care provider prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

THE INFORMATION IN THIS WEBSITE IS OFFERED FOR GENERAL EDUCATIONAL PURPOSES ONLY AND DOES NOT IMPLY OR GIVE MEDICAL ADVICE. No Doctor/Patient relationship shall be deemed to have arisen simply by reading the information contained on these pages, and you should consult with your personal physician/care giver regarding your medical treatment before undergoing any sort of treatment or therapy.

Published on 10-22-2015
Authors: Riccardo Schweizer, Sudheer K. Ravuri, Jan A. Plock, Kacey G. Marra, Vijay S. Gorantla