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Low Levels of Zinc and Anti-Oxidant Vitamines (A, C & E) in Patients with Sickle Cell Anemia. *

Background : Patients with sickle cell anemia have a higher potential for oxidative damage due to chronic redox imbalance in their red blood cells that often leads to hemolysis, endothelial injury and recurrent vaso-occlusive episodes. In this study, we evaluated plasma levels of the anti-oxidant vitamins A, C,& E and serum level of Zinc along with serum level of Copper (pro-oxidant ).

Patients and methods: 25 adult patients with documented severe sickle cell anemia and frequent painful episodes (12 males & 13 females, aged 29.27 +/– 12.94 years) and 25 matched normal controls were studied. Plasma levels of Vitamins A, C, & E were measured by HPLC technique and serum levels of zinc & copper were measured by atomic absorption spectrometry.

Results: These results indicate that levels of Vitamines A, C, and E and Zinc are significantly low in patients with sickle cell anemia in comparison with matched normal controls. Besides, Copper level, which is a well known pro-oxidant, is significantly higher in sickle cell anemia patients. Therefore, supplementing sickle cell anemia patients with anti-oxidant vitamins and trace elements may contribute to the amilioration of symptoms and severity of sickle cell anemia

* Legal Disclaimer: Chelation and Hyperbaric Therapy, Stem Cell Therapy, and other treatments and modalities mentioned or referred to in this web site are medical techniques that may or may not be considered “mainstream”. As with any medical treatment, results will vary among individuals, and there is no implication or guarantee that you will heal or achieve the same outcome as patients herein.

As with any procedure, there could be pain or other substantial risks involved. These concerns should be discussed with your health care provider prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

THE INFORMATION IN THIS WEBSITE IS OFFERED FOR GENERAL EDUCATIONAL PURPOSES ONLY AND DOES NOT IMPLY OR GIVE MEDICAL ADVICE. No Doctor/Patient relationship shall be deemed to have arisen simply by reading the information contained on these pages, and you should consult with your personal physician/care giver regarding your medical treatment before undergoing any sort of treatment or therapy.

Published on 02-18-2007