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Lipoic Acid in Multiple Sclerosis: A Pilot Study *

In a study of 37 multiple sclerosis patients, subjects were randomized to 4 groups, including placebo (2 male and 7 female subjects, median age 50 years); alpha lipoic acid at 600 mg, 2 times daily (1 male and 6 female subjects, median age 49 years); alpha lipoic acid at 1,200 mg, once daily (1 male and 8 female subjects, median age 54 years); and alpha lipoic acid at 1,200 mg of lipoic acid, twice daily (0 male and 8 female subjects, median age 44.5 years), administered for 14 days. Subjects who took 1,200 mg of lipoic acid daily had significantly higher peak serum lipoic acid levels compared with those who took 600 mg, and the peak levels varied considerably among subjects. There was a significant negative correlation between peak serum lipoic acid levels and mean changes in serum metalloproteinase-9 levels. There was a significant dose response relationship between lipoic acid and mean change in serum soluble intercellular adhesion molecule-1 levels. This study suggests that oral lipoic acid is well tolerated and may be able to reduce serum metalloproteinase-9 and soluble intercellular adhesion molecule-1. Lipoic acid may be beneficial in treating multiple sclerosis by inhibiting metalloproteinase-9 activity and interfering with T-cell migration into the central nervous system.

* Legal Disclaimer: Chelation and Hyperbaric Therapy, Stem Cell Therapy, and other treatments and modalities mentioned or referred to in this web site are medical techniques that may or may not be considered “mainstream”. As with any medical treatment, results will vary among individuals, and there is no implication or guarantee that you will heal or achieve the same outcome as patients herein.

As with any procedure, there could be pain or other substantial risks involved. These concerns should be discussed with your health care provider prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

THE INFORMATION IN THIS WEBSITE IS OFFERED FOR GENERAL EDUCATIONAL PURPOSES ONLY AND DOES NOT IMPLY OR GIVE MEDICAL ADVICE. No Doctor/Patient relationship shall be deemed to have arisen simply by reading the information contained on these pages, and you should consult with your personal physician/care giver regarding your medical treatment before undergoing any sort of treatment or therapy.

Published on 04-23-2010
Authors: Yadav V, Marracci G, et al
Source: Multiple Sclerosis, 2005;11:159-165