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High-dose intravenous vitamin C improves quality of life in cancer patients *


High-dose intravenous vitamin C (IVC) therapy has been safely employed for at least 30 years as one form of complementary alternative medical treatments for cancer. We prospectively examined the effects of IVC on the quality of life (QOL) in cancer patients in a multicenter observational study.


This study involved 60 patients with newly diagnosed cancer who visited participating institutions in Japan between June and December 2010 for IVC as an adjuvant cancer therapy. Using the QOL questionnaire developed by the European Organization of Research and Treatment of Cancer (EORTC), EORTC-QLQ C30, QOL was assessed before, and at 2 and 4 weeks of IVC therapy.


The global health/QOL score significantly improved from 44.6 ± 27.8 to 53.2 ± 26.5 (p < 0.05) at 2 weeks and to 61.4 ± 24.3 (p < 0.01) at 4 weeks. Patients also showed significant increases in physical, role, emotional, cognitive, and social functioning at 4 weeks after IVC (p < 0.05). In the symptom scale, significant relief was observed, especially in the score of fatigue, pain, insomnia, constipation, and financial difficulties.

According to the Clinical Global Impression of Change (CGIC), attending physicians evaluated the QOL of their patients as minimally to much improved in 46.7% (28/60) and 60.0% (30/60) at 2 and 4 weeks after IVC, respectively. Only 2 patients at 2 weeks and 3 patients at 4 weeks were evaluated as minimally worse. Moreover, all adverse events were mild, and none of the patients discontinued the therapy because of adverse reactions to IVC.


IVC can safely improve the QOL of cancer patients. These results warrant the conduct of prospective comparative studies to evaluate the usefulness of IVC for patients with advanced cancer.

* Legal Disclaimer: Chelation and Hyperbaric Therapy, Stem Cell Therapy, and other treatments and modalities mentioned or referred to in this web site are medical techniques that may or may not be considered “mainstream”. As with any medical treatment, results will vary among individuals, and there is no implication or guarantee that you will heal or achieve the same outcome as patients herein.

As with any procedure, there could be pain or other substantial risks involved. These concerns should be discussed with your health care provider prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

THE INFORMATION IN THIS WEBSITE IS OFFERED FOR GENERAL EDUCATIONAL PURPOSES ONLY AND DOES NOT IMPLY OR GIVE MEDICAL ADVICE. No Doctor/Patient relationship shall be deemed to have arisen simply by reading the information contained on these pages, and you should consult with your personal physician/care giver regarding your medical treatment before undergoing any sort of treatment or therapy.

Published on 03-01-2013