Close-up TV News - Prolotheray lecture

Reversing Hypertension

Heavy Metals and all diseases

Close-Up TV News - Dr. Calapai's approach

News 12 Interview: Parkinson’s Disease, Glutathione and Chelation Therapy

News 12 Interview: Platelet-rich plasma therapy

Prolotherapy Interview News 12

News 12 Interview: Diabetes and Weight Loss
Helicobacter pylori-induced peptic ulcer disease is associated with inadequate regulatory T-cell responses *

Background & AIMS: Helicobacter pylori infection is the major cause of peptic ulceration and gastric adenocarcinoma. To address the hypothesis that the human acquired immune response to H. pylori influences pathogenesis, we characterised the gastric T-helper (Th) and regulatory T-cell (Treg) response of infected patients.
METHODS: The human gastric CD4+ T-cell response of 28 H. pylori-infected and 44 uninfected donors was analysed using flow cytometry. The T-cell associated mucosal cytokine response was analysed by real-time PCR assay of samples from 38 infected and 22 uninfected donors. Recombinant IL-10 was added to co-cultures of H. pylori and AGS cells and its suppressive effects upon inflammatory responses were measured.
RESULTS: We found that the H. pylori-specific response consists of both T-helper 1 and 2 subsets with high levels of interleukin-10-secreting Tregs. Individuals with peptic ulcer disease had a 2.4-fold reduced CD4+CD25hiIL-10+ Treg response (p=0.05) but increased Th1 and Th2 responses (Th1: 3.2-fold, p=0.038; Th2: 6.1-fold, p=0.029) compared to those without ulcers. In vitro studies showed that IL-10 inhibited H. pylori-induced gastric epithelial cell IL-8 expression and NF-kB activation, and enhanced H. pylori growth in a bacterial-cell co-culture model.
CONCLUSIONS: Together our data suggest that H. pylori induces a regulatory T-cell response, possibly contributing to its peaceful coexistence with the human host, and that ulcers occur when this regulatory response is inadequate.

* Legal Disclaimer: Chelation and Hyperbaric Therapy, Stem Cell Therapy, and other treatments and modalities mentioned or referred to in this web site are medical techniques that may or may not be considered “mainstream”. As with any medical treatment, results will vary among individuals, and there is no implication or guarantee that you will heal or achieve the same outcome as patients herein.

As with any procedure, there could be pain or other substantial risks involved. These concerns should be discussed with your health care provider prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

THE INFORMATION IN THIS WEBSITE IS OFFERED FOR GENERAL EDUCATIONAL PURPOSES ONLY AND DOES NOT IMPLY OR GIVE MEDICAL ADVICE. No Doctor/Patient relationship shall be deemed to have arisen simply by reading the information contained on these pages, and you should consult with your personal physician/care giver regarding your medical treatment before undergoing any sort of treatment or therapy.

Published on 06-19-2008