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he effects of cadmium on placental endocrine function *

Cadmium is a ubiquitous trace metal in the environment and a constituent of tobacco smoke. It is sequestered in the placenta, where it accumulates with advancing gestation, potentially inhibiting the synthesis and/or release of hormones produced by the trophoblast. It is also possible that cadmium competes with essential metals for binding to metallothionein, thus interfering with the transport of these micronutrients to the developing fetus. Experiments in our laboratory indicate that the production of p r o g e s t e r o n e by syncytiotrophoblast cells in vitro is inhibited by cadmium and that this inhibition may be due to a decline in low density lipoprotein-receptor transcription. Although syncytiotrophoblastic maturation does not appear to be affected by cadmium exposure, further studies will be needed to determine the metal's potential effect on cytotrophoblastic invasion of the uterine endometrium in early gestation.

* Legal Disclaimer: Chelation and Hyperbaric Therapy, Stem Cell Therapy, and other treatments and modalities mentioned or referred to in this web site are medical techniques that may or may not be considered “mainstream”. As with any medical treatment, results will vary among individuals, and there is no implication or guarantee that you will heal or achieve the same outcome as patients herein.

As with any procedure, there could be pain or other substantial risks involved. These concerns should be discussed with your health care provider prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

THE INFORMATION IN THIS WEBSITE IS OFFERED FOR GENERAL EDUCATIONAL PURPOSES ONLY AND DOES NOT IMPLY OR GIVE MEDICAL ADVICE. No Doctor/Patient relationship shall be deemed to have arisen simply by reading the information contained on these pages, and you should consult with your personal physician/care giver regarding your medical treatment before undergoing any sort of treatment or therapy.

Published on 09-01-2009
Authors: HENSON Michael C. (1 2), ; ANDERSON Mary B. (2 3 4),
Source: Recent research developments in endocrinology. Vol. 1 (2000), ; Part I pp. 37-47