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Guillain‐Barre Syndrome and Influenza Virus Infection *

Background. In Western countries, the cause of 60% of all Guillain‐Barre syndrome (GBS) cases remains unidentified. The number of cases of unidentified cause peaks in winter, and these cases are commonly preceded by respiratory tract infection or influenza‐like illness. We investigated the triggering role of influenza virus infection.

Methods. Of 405 patients with GBS who were admitted to a French reference center during 1996–2004, 234 had cases caused by an unidentified agent. We used time‐series methods to study the correlation between the monthly incidence of such cases and influenza‐like illnesses reported by the Sentinelles surveillance network. We analyzed anti‐influenza antibodies using complement fixation testing and hemagglutination‐inhibition assays. We studied etiological subgroups using Wilcoxon and Fisher’s exact tests.

Results. We found a positive association between the monthly incidence of GBS caused by an unidentified agent and reported influenza‐like illnesses. Of 73 patients whose cases occurred during periods in which there was a possible link to influenza, 10 (13.7%) had serological evidence of recent influenza A, and 4 (5.5%) had serological evidence of influenza B. Eight of 10 influenza A–related cases occurred during “major” influenza seasons, and antibodies specific to the current epidemic strain were found in 9 cases. Most patients with influenza A–related cases were aged <65 years, and none had antiganglioside antibodies. Influenza‐related cases differed both from Campylobacter jejuni–related cases, with regard to the lack of need for mechanical ventilation ( P = .0,14), and from the cases caused by an unidentified agent, with regard to the presence of preceding influenza‐like illness or respiratory tract infection ( P = .0,15) and longer time from the infectious event to GBS onset (P = .0,4 ).

Conclusions. Influenza viruses are infrequent triggering agents of GBS but may play a significant role during major influenza outbreaks. Influenza‐related GBS displays specific features and is not associated with antiganglioside antibody response, which suggests the presence of underlying immune mechanisms.

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As with any procedure, there could be pain or other substantial risks involved. These concerns should be discussed with your health care provider prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

THE INFORMATION IN THIS WEBSITE IS OFFERED FOR GENERAL EDUCATIONAL PURPOSES ONLY AND DOES NOT IMPLY OR GIVE MEDICAL ADVICE. No Doctor/Patient relationship shall be deemed to have arisen simply by reading the information contained on these pages, and you should consult with your personal physician/care giver regarding your medical treatment before undergoing any sort of treatment or therapy.

Published on 11-06-2009
Authors: Valerie Sivadon?Tardy,1,2 David Orlikowski,2,3 Raphael Porcher,5,6 Tarek Sharshar,2,3 Marie?Christine Durand,2,4 Vincent Enouf,7,8 Flore Rozenberg,9,10 Christiane Caudie,11 Djillali Annane,2,3 Sylvie van der Werf,7,8 Pierre Lebon,9,10 Jean?Claude Raphael,2,3 Jean?Louis Gaillard,1,2 and Elyanne Gault 1,2,7,8
Source: Clinical Infectious Diseases Volume 48, Number S1, 1 January 2009 Supplement, pp. S1-30