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Effects of Alpha-Lipoic Acid Supplementation in Peripheral Arterial Disease: A Pilot Study *

Objective: To examine whether 3 months of lipoic acid (LA) supplementation improved walking tolerance and delayed claudication pain onset in peripheral arterial disease (PAD).

Design: Randomized, double-blind, controlled study.

Setting: General Clinical Research Center.

Subjects: Twenty-eight (28) participants (15 men, 13 women) with PAD (ankle brachial index range 0.9–0.4, mean age 73.2 ± 1.6 years).

Intervention: LA (600 mg/day) or placebo for 3 months.

Outcome measures: Walking tolerance was assessed by 6-minute walk test distance, 4-meter walk time, initial claudication pain time (ICT) and distance (ICD), and peak claudication pain. Serum was assessed for inflammation (C-reactive protein [CRP]) and oxidative stress (lipid hydroperoxides) as potential mechanisms for changes in walking tolerance.

Results: ICT increased 34.4% and 15%, ICD was reduced by 40.5% and 18%, and peak claudication pain ratings were reduced by 93% and 7% in LA and placebo groups, respectively. Although the improvements in peak pain and ICT achieved significance within the LA group (both p < 0.05), the interactions of group by time were not found to be significant (p > 0.05). Oxidative stress and CRP measures were not different between groups by month 3 (p > 0.05). There were no serious side-effects associated with the LA.

* Legal Disclaimer: Chelation and Hyperbaric Therapy, Stem Cell Therapy, and other treatments and modalities mentioned or referred to in this web site are medical techniques that may or may not be considered “mainstream”. As with any medical treatment, results will vary among individuals, and there is no implication or guarantee that you will heal or achieve the same outcome as patients herein.

As with any procedure, there could be pain or other substantial risks involved. These concerns should be discussed with your health care provider prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

THE INFORMATION IN THIS WEBSITE IS OFFERED FOR GENERAL EDUCATIONAL PURPOSES ONLY AND DOES NOT IMPLY OR GIVE MEDICAL ADVICE. No Doctor/Patient relationship shall be deemed to have arisen simply by reading the information contained on these pages, and you should consult with your personal physician/care giver regarding your medical treatment before undergoing any sort of treatment or therapy.

Published on 08-18-2008
Authors: Heather K. Vincent, Cheryl M. Bourguignon, Kevin R. Vincent, Ann G. Taylor
Source: The Journal of Alternative and Complementary Medicine