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Effects of a ketogenic diet on the quality of life in 16 patients with advanced cancer: A pilot trial *

Tumor patients exhibit an increased peripheral demand of fatty acids and protein. Contrarily, tumors
utilize glucose as their main source of energy supply. Thus, a diet supplying the cancer patient with sufficient fat
and protein for his demands while restricting the carbohydrates (CHO) tumors thrive on, could be a helpful
strategy in improving the patients
situation. A ketogenic diet (KD) fulfills these requirements. Therefore, we
performed a pilot study to investigate the feasibility of a KD and its influence on the quality of life of patients with
advanced metastatic tumors.
Sixteen patients with advanced metastatic tumors and no conventional therapeutic options participated
in the study. The patients were instructed to follow a KD (less than 70 g CHO per day) with normal groceries and
were provided with a supply of food additives to mix a protein/fat shake to simplify the 3-month intervention
period. Quality of life [assessed by EORTC QLQ-C30 (version 2)], serum and general health parameters were
determined at baseline, after every two weeks of follow-up, or after drop out. The effect of dietary change on
metabolism was monitored daily by measuring urinary ketone bodies.
One patient did not tolerate the diet and dropped out within 3 days. Among those who tolerated the
diet, two patients died early, one stopped after 2 weeks due to personal reasons, one felt unable to stick to the
diet after 4 weeks, one stopped after 6 and two stopped after 7 and 8 weeks due to progress of the disease, one
had to discontinue after 6 weeks to resume chemotherapy and five completed the 3 month intervention period.
These five and the one who resumed chemotherapy after 6 weeks report an improved emotional functioning and
less insomnia, while several other parameters of quality of life remained stable or worsened, reflecting their very
advanced disease. Except for temporary constipation and fatigue, we found no severe adverse side effects,
especially no changes in cholesterol or blood lipids.
These pilot data suggest that a KD is suitable for even advanced cancer patients. It has no severe
side effects and might improve aspects of quality of life and blood parameters in some patients with advanced
metastatic tumors.

* Legal Disclaimer: Chelation and Hyperbaric Therapy, Stem Cell Therapy, and other treatments and modalities mentioned or referred to in this web site are medical techniques that may or may not be considered “mainstream”. As with any medical treatment, results will vary among individuals, and there is no implication or guarantee that you will heal or achieve the same outcome as patients herein.

As with any procedure, there could be pain or other substantial risks involved. These concerns should be discussed with your health care provider prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

THE INFORMATION IN THIS WEBSITE IS OFFERED FOR GENERAL EDUCATIONAL PURPOSES ONLY AND DOES NOT IMPLY OR GIVE MEDICAL ADVICE. No Doctor/Patient relationship shall be deemed to have arisen simply by reading the information contained on these pages, and you should consult with your personal physician/care giver regarding your medical treatment before undergoing any sort of treatment or therapy.

Published on 05-09-2013