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Coenzyme Q10 and Alpha-Lipoic Acid Supplementation – Potential Role in Blood Sugar Imbalance, Insulin Resistance, and the Metabolic Syndrome *

In a study involving fructose-fed male Sprague Dawley rats, administration of alpha-lipoic acid and coenzyme Q10 was found to suppress oxidative and nitrative stress, hyperinsulinemia, and insulin resistance. Rats were divided into 4 groups – Group1 served as a control; Group2 received a regular diet and water ad libitum and fructose; Group3 received alpha-lipoic acid (100 mg/kg/d), i.p., for 5 weeks, and Group4 received coenzyme Q10 (10 mg/kg/d), i.p., for 5 weeks. Rats fed a high-fructose diet were found to have significant elevations in plasma LDL, VLDL, and total cholesterol, as well as plasma asymmetric dimethylarginine, malondialdehyde, and glutathione, while showing a decrease in HDL cholesterol. Administration of alpha-lipoic acid and coenzyme Q10 was found to notably suppress oxidative stress, nitrative stress, hyperinsulinemia, and insulin resistance. These results in animals suggest that coenzyme Q10 and alpha-lipoic acid may have a positive effect on markers of the metabolic syndrome. Additional research is warranted.

* Legal Disclaimer: Chelation and Hyperbaric Therapy, Stem Cell Therapy, and other treatments and modalities mentioned or referred to in this web site are medical techniques that may or may not be considered “mainstream”. As with any medical treatment, results will vary among individuals, and there is no implication or guarantee that you will heal or achieve the same outcome as patients herein.

As with any procedure, there could be pain or other substantial risks involved. These concerns should be discussed with your health care provider prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

THE INFORMATION IN THIS WEBSITE IS OFFERED FOR GENERAL EDUCATIONAL PURPOSES ONLY AND DOES NOT IMPLY OR GIVE MEDICAL ADVICE. No Doctor/Patient relationship shall be deemed to have arisen simply by reading the information contained on these pages, and you should consult with your personal physician/care giver regarding your medical treatment before undergoing any sort of treatment or therapy.

Published on 10-31-2012