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Chemotherapy can inadvertently trigger cancer resistance *

Scientists may have a better understanding as to why some people become resistant to chemotherapy treatment, the BBC News reported.

According to a new study in Nature Medicine, researchers found the therapy can cause healthy wound-healing cells around tumors to “go rogue” and produce a protein that helps the cancer to resist the chemo.

Adapting to this effect could help a large number of patients, the BBC News said. For about 90 percent of patients with solid cancers that spread – including breast, prostate, lung and colon – they eventually develop chemotherapy resistance.

Conducted by researchers at the Fred Hutchinson Cancer Research Center in Seattle, the study analyzed fibroblast cells, which are critically involved in wound healing and collagen production. The scientists found chemotherapy caused DNA damage that, in turn, triggered the fibroblasts to produce 30 times more WNT 16B protein than normal.

According to the study, the WNT 16B protein helps cancer cells to grow and invade surrounding tissue, as well as developing a resistant to chemotherapy.


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As with any procedure, there could be pain or other substantial risks involved. These concerns should be discussed with your health care provider prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

THE INFORMATION IN THIS WEBSITE IS OFFERED FOR GENERAL EDUCATIONAL PURPOSES ONLY AND DOES NOT IMPLY OR GIVE MEDICAL ADVICE. No Doctor/Patient relationship shall be deemed to have arisen simply by reading the information contained on these pages, and you should consult with your personal physician/care giver regarding your medical treatment before undergoing any sort of treatment or therapy.

Published on 06-05-2014