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Bone Marrow Mesenchymal Stromal Cell Transplantation: A Neurorestorative Therapy for Stroke *

A decade long focus on neuroprotection for stroke and neural injury, and its failure to translate into the clinical setting has led to a major shift of focus from neuroprotection to neurorestoration. Neurorestoration involves the remodeling and rekindling of neurovascular plasticity within the central nervous system which drive neurological recovery. Bone marrow-derived mesenchymal stem cell (BMSC) therapy is a promising cell-based neurorestorative therapy for stroke. This chapter provides an update on the use of BMSCs to promote neurorestorative effects in the sub-acute and chronic phases after stroke. The biological processes involved in promoting neurorestorative effects post ischemia are outlined, molecular mechanisms that promote neurogenesis, synaptogenesis, vascular and white matter remodeling, and neurovascular interactions and plasticity are discussed, the involvement of microRNA’s in regulating neurorestorative mechanisms is introduced, and an update on clinical trials for BMSC treatment of stroke is presented.

* Legal Disclaimer: Chelation and Hyperbaric Therapy, Stem Cell Therapy, and other treatments and modalities mentioned or referred to in this web site are medical techniques that may or may not be considered “mainstream”. As with any medical treatment, results will vary among individuals, and there is no implication or guarantee that you will heal or achieve the same outcome as patients herein.

As with any procedure, there could be pain or other substantial risks involved. These concerns should be discussed with your health care provider prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

THE INFORMATION IN THIS WEBSITE IS OFFERED FOR GENERAL EDUCATIONAL PURPOSES ONLY AND DOES NOT IMPLY OR GIVE MEDICAL ADVICE. No Doctor/Patient relationship shall be deemed to have arisen simply by reading the information contained on these pages, and you should consult with your personal physician/care giver regarding your medical treatment before undergoing any sort of treatment or therapy.

Published on 04-06-2016
Authors: Jieli Chen, Poornima Venkat, Michael Chopp
Source: Cellular Therapy for Stroke and CNS Injuries