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Bone marrow- and cord blood-derived stem cell transplantation for diabetestherapy *

In the last years, the widely consolidated clinical experience in the field of hematology has encouraged the use of bone marrow (BM)- and cord blood (CB)-derived stem cells in nonhaematological disease. In the field of diabetes, a huge amount of clinical trials for the cure of type 1 and type 2 diabetes, involving BM-derived HSC and both BM- and CB-derived MSC got underway, thanks also to the availability of simple protocols for collection, culture and storage of these stem cells. Many groups have investigated their potential role in tolerance induction and/or restoration, in pancreatic tissue remodelling as “feeder” cells and in direct differentiation into insulin-producing cells, with the shared final goal to preserve β cell function. This review recapitulates the historical use of BM- and CB-derived stem cells in diabetes therapy, alone or in combination with islet transplantation, and focuses on the most relevant information on preclinical experimental data and provides an update on the most recent clinical trials.

* Legal Disclaimer: Chelation and Hyperbaric Therapy, Stem Cell Therapy, and other treatments and modalities mentioned or referred to in this web site are medical techniques that may or may not be considered “mainstream”. As with any medical treatment, results will vary among individuals, and there is no implication or guarantee that you will heal or achieve the same outcome as patients herein.

As with any procedure, there could be pain or other substantial risks involved. These concerns should be discussed with your health care provider prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

THE INFORMATION IN THIS WEBSITE IS OFFERED FOR GENERAL EDUCATIONAL PURPOSES ONLY AND DOES NOT IMPLY OR GIVE MEDICAL ADVICE. No Doctor/Patient relationship shall be deemed to have arisen simply by reading the information contained on these pages, and you should consult with your personal physician/care giver regarding your medical treatment before undergoing any sort of treatment or therapy.

Published on 03-10-2017
Authors: E. Cantarelli, S. Pellegrini, A. Citro, V. Sordi, L. Piemon