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Basic Studies on the Bone Formation Ability by Platelet Rich Plasma in Rabbits. NYC *

Purpose: Platelets, which contain many growth factors, such as platelet-derived growth factor (PDGF) and transforming growth factor-[beta] (TGF-[beta]), can be obtained in high concentrations by centrifugal separation and are being used as platelet-rich plasma (PRP) in clinical applications. The authors evaluated the bone formation ability by PRP in rabbits.

Materials and Methods: In experiment 1, the authors made platelet precipitations from the whole blood obtained from rabbits. Each precipitated platelet was resuspended in fibrin glue. The glue was applied to a 1-mm wide slit defect of the same rabbit mandible. After 1 week, the authors observed the histologic appearances. In experiment 2, the fibrin glue containing the precipitated platelet was applied to a bicortical defect of a rabbit cranium with [beta]-tricalcium phosphate ([beta]-TCP) granules as artificial bone material. After 1 week, 1 month, and 2 months, the authors observed the radiologic and histologic appearances.

Results and Conclusions: In both experiments, a prosperous bone formation was observed from the beginning more in the group treated with PRP than in the group untreated. In experiment 2, gradual appearances of the bone formation were observed in the bubble of [beta]-TCP. In application with artificial bone materials, bone formations by PRP were suitably observed.

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As with any procedure, there could be pain or other substantial risks involved. These concerns should be discussed with your health care provider prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

THE INFORMATION IN THIS WEBSITE IS OFFERED FOR GENERAL EDUCATIONAL PURPOSES ONLY AND DOES NOT IMPLY OR GIVE MEDICAL ADVICE. No Doctor/Patient relationship shall be deemed to have arisen simply by reading the information contained on these pages, and you should consult with your personal physician/care giver regarding your medical treatment before undergoing any sort of treatment or therapy.

Published on 06-01-2009
Authors: Yazawa, Masaki MD *; Ogata, Hisao MD *; Kimura, Akiko MD *; Nakajima, Tatsuo MD *; Mori, Taisuke DDS +; Watanabe, Naohide MD ++
Source: Journal of Craniofacial Surgery. 15(3),:439-446, May 2004.