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Alpha-Lipoic Acid Protects Against Radiation-Induced Cognitive Dysfunction *

In a study involving mice, the antioxidant alpha-lipoic acid was found to attenuate cognitive dysfunction induced by radiation. Mice exposed to whole-body X-irradiation (6Gy) were found to have impairment in memory and motor activities. When mice were given acute intraperitoneal treatment with alpha-lipoic acid prior to irradiation, the effects of the radiation on cognitive function were significantly attenuated. Specifically, ALA was found to protect against radiation-induced augmentation of protein carbonyls and TBARS in the cerebellum and deficit of total, nonprotein, and protein-bound sulfhydryl contents of cerebellum and plasma ferric reducing power. Furthermore, compared to untreated mice exposed to radiation, the mice treated with ALA were found to have an intact cytoarchitecture of the cerebellum and higher counts of Purkinje cells and granular cells. The results of this study suggest that alpha-lipoic acid has potent neuroprotective properties and may protect against radiation-induced cognitive dysfunction and cerebellar oxidative stress in mice.

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As with any procedure, there could be pain or other substantial risks involved. These concerns should be discussed with your health care provider prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

THE INFORMATION IN THIS WEBSITE IS OFFERED FOR GENERAL EDUCATIONAL PURPOSES ONLY AND DOES NOT IMPLY OR GIVE MEDICAL ADVICE. No Doctor/Patient relationship shall be deemed to have arisen simply by reading the information contained on these pages, and you should consult with your personal physician/care giver regarding your medical treatment before undergoing any sort of treatment or therapy.

Published on 03-12-2010
Authors: Manda K, Ueno M, et al
Source: Behavioural Brain Research, 2007; 177(1): 7-14