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Alpha-Lipoic Acid May Benefit Patients with Rheumatoid Arthritis *

In a study involving mice, alpha-lipoic acid was found to attenuate the development of collagen-induced arthritis (CIA) in a dose-dependent manner. The mice were divided into three groups. Group1 received alpha-lipoic acid (ALA) 10 mg/kg; Group2 received ALA 100 mg/kg; and Group3 received a placebo. Results found that mice treated with lipoic acid experienced a dose-dependent reduction in CIA. Furthermore, bone erosion and destructive changes were prevented with ALA administration in vivo, and formation of osteoclasts was inhibited in vitro. Levels of intracellular reactive oxygen species, and concentrations of TNF-alpha, IL-1 beta, IL-6, and synovial NF-kappa B binding were found to be markedly higher among mice with CIA as compared to controls; after treatment with alpha-lipoic acid, these levels decreased significantly. The authors of this study conclude, "these results indicate that alpha-lipoic acid may be a new adjunctive therapy for rheumatoid arthritis."

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As with any procedure, there could be pain or other substantial risks involved. These concerns should be discussed with your health care provider prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

THE INFORMATION IN THIS WEBSITE IS OFFERED FOR GENERAL EDUCATIONAL PURPOSES ONLY AND DOES NOT IMPLY OR GIVE MEDICAL ADVICE. No Doctor/Patient relationship shall be deemed to have arisen simply by reading the information contained on these pages, and you should consult with your personal physician/care giver regarding your medical treatment before undergoing any sort of treatment or therapy.

Published on 03-12-2010
Authors: Lee EY, Lee CK, et al
Source: Rheumatology International, 2007; 27(3): 225-233