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Alpha-Lipoic Acid as a New Treatment for Patients with Alzheimer's disease *

In a study involving 43 patients with Alzheimer's disease (mild or moderate), supplementation with alpha-lipoic acid (600 mg/day) was found to be associated with dramatically lower progression of the disease over a period of 48 months, as compared to data from patients not receiving alpha-lipoic acid. The authors first cite a previous open-label study in which 9 patients with Alzheimer's disease (AD) receiving standard treatment with choline-esterase inhibitors were given 600 mg/day alpha-lipoic acid for a period of 12 months. The results of that study found stabilization of cognitive functions as assessed via 2 neuropsychological tests. In this study, the authors extended the analysis to include 43 patients over the course of 48 months. Results found that in patients with mild dementia (ADAScog <15), progression of the disease was extremely slow and in patients with moderate dementia (ADAScog: +1.2 points/year; MMSE: -0.6 points/year), progression of the disease was twice that rate. Compared with data from untreated patients or patients on choline-esterase inhibitors alone, the progression of the disease was dramatically lower among the subjects in this study taking alpha-lipoic acid. The authors conclude, "Despite the fact that this study was not double-blinded, placebo-controlled and randomized, our data suggest that treatment with alpha-lipoic acid might be a successful 'neuroprotective' therapy option for AD. However, a state-of-the-art phase II trial is needed urgently."

* Legal Disclaimer: Chelation and Hyperbaric Therapy, Stem Cell Therapy, and other treatments and modalities mentioned or referred to in this web site are medical techniques that may or may not be considered “mainstream”. As with any medical treatment, results will vary among individuals, and there is no implication or guarantee that you will heal or achieve the same outcome as patients herein.

As with any procedure, there could be pain or other substantial risks involved. These concerns should be discussed with your health care provider prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

THE INFORMATION IN THIS WEBSITE IS OFFERED FOR GENERAL EDUCATIONAL PURPOSES ONLY AND DOES NOT IMPLY OR GIVE MEDICAL ADVICE. No Doctor/Patient relationship shall be deemed to have arisen simply by reading the information contained on these pages, and you should consult with your personal physician/care giver regarding your medical treatment before undergoing any sort of treatment or therapy.

Published on 03-12-2010
Authors: Hager K, Kenklies M, et al
Source: J Neural Transm Suppl, 2007; 72: 189-93