SERVICES*

Close-up TV News - Prolotheray lecture

Reversing Hypertension

Heavy Metals and all diseases

Close-Up TV News - Dr. Calapai's approach

News 12 Interview: Parkinson’s Disease, Glutathione and Chelation Therapy

News 12 Interview: Platelet-rich plasma therapy

Prolotherapy Interview News 12

News 12 Interview: Diabetes and Weight Loss
Alpha lipoic acid: a new treatment for neuropathic pain in patients with diabetes? *

Background: Neuropathic pain is difficult to treat. We
identified those studies in the literature in which the
effectiveness of alpha lipoic acid as a treatment for
neuropathic pain was evaluated.
Methods: Systematic literature review. The databases
MEDLINE and EMBASE were searched using the keywords
“lipoic acid”, “thioctic acid”, “diabet*”, and the medical
subject headings (MeSH ) “thioctic acid” and “diabetes
mellitus”. Randomised placebo-controlled trials (RCTs)
and meta-analyses were selected and assessed for their
methodological quality.
Results: Five RCTs and one meta-analysis were found.
The Total Symptom Score (TSS ) was used as the primary
outcome measure. A significant improvement in the TSS
was reported in four of the RCTs. An oral or intravenous
alpha lipoic dose of at least 600 mg per day resulted in a
50% reduction in the TSS . However, compared with the
control group, the TSS reduction in most groups was less
than 30%, which is the threshold presumed to be clinically
relevant. Four RCTs were of good quality (level of evidence
1b), one RCT had methodological limitations (level 2b),
and the methodological quality of the meta-analysis was
insufficient for the purposes of this review.
Conclusion: Based on the currently available evidence,
when given intravenously at a dosage of 600 mg once daily
over a period of three weeks, alpha lipoic acid leads to a
significant and clinically relevant reduction in neuropathic
pain (grade of recommendation A). It is unclear if the
significant improvements seen after three to five weeks
of oral administration at a dosage of ≥600 mg daily are
clinically relevant.

* Legal Disclaimer: Chelation and Hyperbaric Therapy, Stem Cell Therapy, and other treatments and modalities mentioned or referred to in this web site are medical techniques that may or may not be considered “mainstream”. As with any medical treatment, results will vary among individuals, and there is no implication or guarantee that you will heal or achieve the same outcome as patients herein.

As with any procedure, there could be pain or other substantial risks involved. These concerns should be discussed with your health care provider prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

THE INFORMATION IN THIS WEBSITE IS OFFERED FOR GENERAL EDUCATIONAL PURPOSES ONLY AND DOES NOT IMPLY OR GIVE MEDICAL ADVICE. No Doctor/Patient relationship shall be deemed to have arisen simply by reading the information contained on these pages, and you should consult with your personal physician/care giver regarding your medical treatment before undergoing any sort of treatment or therapy.

Published on 09-18-2012