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Adipose Tissue-Derived Mesenchymal Stem Cell and Angiogenesis in Ischemic Heart Disease *

Acute myocardial infarction is one of the most important causes of death and disability worldwide. The limited capacity of the adult heart to self-regenerate and revascularize the ischemic damaged tissue leads to tissue loss, ventricular remodeling, and persistent deterioration in cardiac performance increasing the frequency of heart failure. Over the last several years, adult stem cells have appeared as one of the novel promising therapeutic approaches for the treatment of ischemic heart disease. However, the quest for the best cell type is still ongoing. This ideal cell type should be capable of differentiating into functional cardiomyocytes and of forming new vessels to nourish the damaged area. Recent studies have shown that adipose tissue contains multipotent stem cells (the so-called adipose tissue-derived stem cells or ASC) that are capable of regenerating injured myocardium by differentiating into cardiac resident cells or by secreting multiple angiogenic growth factors (paracrine effects). Moreover, due to ease of harvesting these cells in large numbers and low immunogenicity, white adipose tissue has become an attractive stem cell source. In this chapter, we review the principal characteristics of ASC as well as their capacity to repair cardiac damage in the setting of ischemic heart disease as compared with other adult stem cells, with special attention to their pro-­angiogenic mechanisms of action.


* Legal Disclaimer: Chelation and Hyperbaric Therapy, Stem Cell Therapy, and other treatments and modalities mentioned or referred to in this web site are medical techniques that may or may not be considered “mainstream”. As with any medical treatment, results will vary among individuals, and there is no implication or guarantee that you will heal or achieve the same outcome as patients herein.

As with any procedure, there could be pain or other substantial risks involved. These concerns should be discussed with your health care provider prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

THE INFORMATION IN THIS WEBSITE IS OFFERED FOR GENERAL EDUCATIONAL PURPOSES ONLY AND DOES NOT IMPLY OR GIVE MEDICAL ADVICE. No Doctor/Patient relationship shall be deemed to have arisen simply by reading the information contained on these pages, and you should consult with your personal physician/care giver regarding your medical treatment before undergoing any sort of treatment or therapy.

Published on 12-31-2014