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Adipose-derived mesenchymal stem cells and regenerative medicine *

Recently, adipose tissue has been reported as a source of adult stem cells (Hombach-Klonisch et al. 2008). A high yield of adipose-derived mesenchymal stem cells (ADSCs) can be obtained with minimal discomfort under local anesthesia (Casteilla & Dani 2006). Following reports by Zuk et al. (2001, 2002), many studies have examined the characteristics, plasticity, and inducibility of ADSCs. Embryonic mesoderm-derived adipose tissue comprises a heterogeneous population of smooth muscle cells, fibroblasts, adipocytes, mast cells, and endothelial cells (Hausman 1981; Hausman & Campion 1982; Pettersson et al. 1984). ADSCs are adherent in vitro, maintaining their mesenchymal phenotype and plasticity toward the mesenchymal lineage after many passages in culture. These cells have been molecularly characterized using a panel of multiple mesenchymal differentiation markers (Lee et al. 2004; Dicker et al. 2005;Wagner et al. 2005; Oedayrajsingh-Varma et al. 2006; Table 1). In addition, they have been found to differentiate into multiple cell types in vitro, including adipocytes, chondrocytes, osteoblasts, cardiomyocytes, and vascular endothelial cells (Majumdar et al. 2000; Zuk et al. 2001; Halvorsen et al. 2000, 2001; Rangappa et al. 2003; Planat-Benard et al. 2004b; ; Konno et al. 2010). Moreover, ADSCs reportedly exert positive effects on patients with graft-versus-host disease occurring after bone marrow transplantation, suggesting an immunomodulatory function (Lombardo et al. 2009). In this review, we describe the methods and mechanisms underlying ADSC differentiation into multilineage cells.

* Legal Disclaimer: Chelation and Hyperbaric Therapy, Stem Cell Therapy, and other treatments and modalities mentioned or referred to in this web site are medical techniques that may or may not be considered “mainstream”. As with any medical treatment, results will vary among individuals, and there is no implication or guarantee that you will heal or achieve the same outcome as patients herein.

As with any procedure, there could be pain or other substantial risks involved. These concerns should be discussed with your health care provider prior to any treatment so that you have proper informed consent and understand that there are no guarantees to healing.

THE INFORMATION IN THIS WEBSITE IS OFFERED FOR GENERAL EDUCATIONAL PURPOSES ONLY AND DOES NOT IMPLY OR GIVE MEDICAL ADVICE. No Doctor/Patient relationship shall be deemed to have arisen simply by reading the information contained on these pages, and you should consult with your personal physician/care giver regarding your medical treatment before undergoing any sort of treatment or therapy.

Published on 01-27-2016
Authors: Masamitsu Konno,Atsushi Hamabe,Shinichiro Hasegawa, Hisataka Ogawa,Takahito Fukusumi,Shimpei Nishikawa, Katsuya Ohta,Yoshihiro Kano, Miyuki Ozaki, Yuko Noguchi,Daisuke Sakai, Toshihiro Kudoh, Koichi Kawamoto,Hidetoshi Eguchi,Taroh Satoh, Masahiro Tanemura, Hiroaki Nagano, Yuichiro Doki, Masaki Mori and Hideshi Ishii
Source: The Japanese Society of Developmental Biologists