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Use of Autologous Platelet-Rich Plasma in the Treatment of Dormant Corneal Ulcers Connecticut

Purpose To investigate the potential role of autologous platelet-rich plasma in promoting healing in dormant corneal ulcers.

Prospective, consecutive, interventional, noncomparative, nonrandomized, observational study.

Forty eyes of 38 patients with dormant corneal ulcers.

Autologous platelet-rich plasma was used in a total of 40 eyes with dormant corneal ulcers divided into 2 groups: group I, 26 eyes treated with topical eyedrops of autologous platelet-rich plasma (12 neurotrophic, 9 herpetic, and 5 immunological ulcers), and group II, 14 eyes treated surgically with a solid clot of autologous platelet-rich plasma combined with amniotic membrane transplantation in perforated corneas or with impending perforation. The treatment was used in patients with chronic nonhealing ulcers (mean, 2 years of evolution) that had been unresponsive to conventional topical therapy. Autologous blood from each patient was obtained by venipuncture, and platelet-rich plasma was prepared from each blood sample without additives.

Published on 06-01-2009
Authors: Jorge L. Alio MD, PhD1, 2, Marta Abad PhD3, Alberto Artola MD, PhD1, 2, Jose L. Rodriguez-Prats MD1, Silvia Pastor PhD3 and Jose Ruiz-Colecha MD1
Source: Ophthalmology Volume 114, Issue 7, July 2007, Pages 1286-1293.e1