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The Effect of Magnesium Sulfate on Action Potential Duration and Cardiac Arrhythmias.

To evaluate the electrophysiologic and antiarrhythmic effects, Mg2+ was infused at 15 mg/h (n = 5) or an equal volume of saline (1.2 mL/h) (n = 5) and electrocardiogram and action potential duration (APD) recorded every 15 minutes. Rats were anesthetized with 70 mg/kg pentobarbital intraperitoneally. Mg2+ increased QT 15 +/- 6% on average compared with 1 +/- 4 for saline P < 0.0l. Mg2+ increased QT, 0, 0, 6 +/- 4, 13 +/- 5, 16 +/- 4, 23 +/- 5, 29 +/- 8, and 32 +/- 5% over baseline after a 2 hours infusion (P < 0.01). APD increased by 0, 6 +/- 3, 8 +/- 8, 14 +/- 4, 16 +/- 12, 21 +/- 4, 25 +/- 5% change from baseline (P < 0.05). The mean percentage of increase was 12 +/- 8 for the Mg2+ group and 1 +/- 3 for the saline group (P < 0.05).
The JT interval also increased after Mg2+ (P < 0.01). After Mg2+ loading, coronary occlusion of the left anterior descending coronary artery was performed. Ventricular premature contractions (VPCs), ventricular tachycardia (VT), and ventricular fibrillation (VF) were frequent in the saline control group, with 2 dying in VF; with only scattered VPCs and short runs of nonsustained VT in the Mg2+ group. The results of these findings indicate that infusion of MgSO4 can prolong the QRS, QT, and JT intervals in the rat and these changes correlate well with arrhythmia suppression.
Published on 08-11-2008
Authors: Somberg, John C *; Cao, Wei; Cvetanovic, Ivana; Ranade, Vasant V; Molnar, Janos
Source: American Journal of Therapeutics. 12(3),:218-222, May/June 2005