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The therapeutic potential of human umbilical cord blood-derived mesenchymal stem cells in Alzheimer’s disease


The neuropathological hallmarks of Alzheimer’s disease (AD) include the presence of extracellular amyloid-β peptide (Aβ) in the form of amyloid plaques in the brain parenchyma and neuronal loss. The mechanism associated with neuronal death by amyloid plaques is unclear but oxidative stress and glial activation has been implicated. Human umbilical cord blood-derived mesenchymal stem cells (hUCB-MSCs) are being scrutinized as a potential therapeutic tool to prevent various neurodegenerative diseases including AD. However, the therapeutic impact…

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Repeated peripheral administration of adult mesenchymal stem cells has a positive impact on Abeta amyloid pathology in a transgenic mouse model of Alzheimer’s disease


Alzheimer’s disease (AD) is a neurodegenerative disorder pathologically characterized by extracellular senile plaques, primarily composed of polymerized amyloid-beta (Abeta) peptides. There is currently no cure for this disease that represents one of today’s major healthcare challenges due to its severe socio-economic burden. The huge potential offered by adult ischemic-tolerant mesenchymal stem cells (itMSC) for the treatment of AD and other neurodegenerative disorders is still not fully exploited. URL: http://www.neurobiologyofaging.org/article/S0197-4580%2814%2900060-8/abstract

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Intracerebral Transplantation of Bone Marrow-Derived Mesenchymal Stem Cells Reduces Amyloid-Beta Deposition and Rescues Memory Deficits in Alzheimer’s Disease Mice by Modulation of Immune Responses†‡§


Alzheimer’s disease (AD) is characterized by the deposition of amyloid-β peptide (Aβ) and the formation of neurofibrillary tangles. Transplantation of bone marrow-derived mesenchymal stem cells (BM-MSCs) has been suggested as a potential therapeutic approach to prevent various neurodegenerative disorders, including AD. However, the actual therapeutic impact of BM-MSCs and their mechanism of action in AD have not yet been ascertained. The aim of this study was therefore to evaluate the therapeutic effect of BM-MSC transplantation…

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Conventional rotator cuff repair complemented by the aid of mononuclear autologous stem cells


Purpose To investigate the behavior of rotator cuff tears treated with conventional repair technique with the aid of autologous bone marrow mononuclear cells (BMMC). Methods Fourteen consecutive patients (9 women, 5 men, mean age of 59.2 years) with complete rotator cuff tears (mean preoperative UCLA score of 12 ± 3.0) were fixed by transosseous stitches through mini-open incision, with subsequent injection of BMMC into the tendon borders, obtained from the iliac crest just prior to surgery. Magnetic resonance…

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Intra-articular injection of human meniscus stem/progenitor cells promotes meniscus regeneration and ameliorates osteoarthritis through stromal cell-derived factor-1/CXCR4-mediated homing.


Meniscus injury is frequently encountered in clinical practice. Current surgical therapy involving partial or complete meniscectomy relieves pain in the short-term but often leads to osteoarthritis (OA) in the long-term. In this study, we report a new strategy of articular cartilage protection by intra-articular injection of novel human meniscus stem/progenitor cells (hMeSPCs). We found that hMeSPCs displayed both mesenchymal stem cell characteristics and high expression levels of collagen II. In the rat meniscus injury model,…

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Osteoarthritis Prevention Through Meniscal Regeneration Induced by Intra-Articular Injection of Meniscus Stem Cells


Meniscus injury is frequently encountered in clinical practice. Current surgical therapy involving partial or complete meniscectomy relieves pain in the short-term but often leads to osteoarthritis (OA) in the long-term. Here, this study aimed to identify and characterize a novel population of meniscus-derived stem cells (MeSCs) and develop a new strategy of articular cartilage protection by intra-articular injection of these cells. The “stemness” and immune properties of MeSCs were investigated in vitro, while the efficacy…

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Evaluation of Intra-Articular Mesenchymal Stem Cells to Augment Healing of Microfractured Chondral Defects


Purpose This study evaluated intra-articular injection of bone marrow–derived mesenchymal stem cells (BMSCs) to augment healing with microfracture compared with microfracture alone. Methods Ten horses (aged 2.5 to 5 years) had 1-cm2 defects arthroscopically created on both medial femoral condyles of the stifle joint (analogous to the human knee). Defects were debrided to subchondral bone followed by microfracture. One month later, 1 randomly selected medial femorotibial joint in each horse received an intra-articular injection of…

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Role of mesenchymal stem cells in tissue engineering of meniscus


Tissue engineering is a promising approach for the treatment of tissue defects. Mesenchymal stem cells are of potential use as a source of repair cells or of important growth factors for tissue engineering. The purpose of this study was to examine the role of mesenchymal stem cells in meniscal tissue repair. This was tested using several cell and biomaterial-based treatment options for repair of defects in the avascular zone of rabbit menisci. Circular meniscal punch…

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Mesenchymal stem cells and autoimmune diseases


Mesenchymal stem cell (MSC) immunosuppressive properties offer a potentially attractive therapeutic modality for autoimmune diseases. MSC inhibit virtually all types of immune responses in vitro and prevent the induction of disease in several experimental models of autoimmunity. However, the processes involved in the pathogenesis of human diseases are more complicated and treatment cannot be administered before disease induction. In autoimmune diseases persistent antigenic stimulation recruits endogenous MSC to the site of lesion that contribute to…

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A5.17 Comparison of adipose mesenchymal stem cells derived from rheumatoid arthritis and osteoarthritis patients. The influence of adipocytokines


Background and Objectives Adipose-derived stem cells (ASCs) have immunomodulatory properties and are intensively studied as a potential therapeutical method to treat rheumatoid arthritis (RA). ASCs immunosuppressive function may be affected by adipocytokines released by intra-articular adipose tissue. Knowing that inflammatory conditions may alter immunoregulatory properties of ASCs, we aimed to verify if there are any differences between ASCs derived from RA and osteoarthritis (OA) patients regarding their influence on synovial fibroblasts (FLS) and peripheral blood…

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